钯催化的胍作为导向基团的 C-H 功能化反应：芳基胍的邻位芳基化和烯烃化。
Palladium-catalyzed C-H functionalization using guanidine as a directing group: ortho arylation and olefination of arylguanidines.
机构信息
Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
出版信息
Org Lett. 2012 Nov 2;14(21):5452-5. doi: 10.1021/ol302533w. Epub 2012 Oct 24.
Abstract
Palladium-catalyzed C-H functionalization using guanidine as the directing group was achieved under mild reaction conditions. Various guanidine derivatives were produced in moderate to good yields by using simple unactivated arenes or ethyl acrylate as the source of arylation or olefination, respectively.
摘要
钯催化的使用胍作为导向基团的 C-H 官能化反应在温和的反应条件下得以实现。通过使用简单的未活化的芳烃或丙烯酸乙酯分别作为芳基化或烯烃化的来源，得到了各种胍衍生物，产率中等至良好。
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