Division of Infectious and Parasitic Diseases, Hospital das Clínicas, University of São Paulo, Medical School, Brazil.
Am J Trop Med Hyg. 2011 Nov;85(5):818-9. doi: 10.4269/ajtmh.2011.11-0287.
Liposomal amphotericin B has been used as an alternative treatment of mucosal leishmaniasis, but the optimal dose is not established. We retrospectively reviewed the clinical outcome of eight patients with mucosal leishmaniasis treated with liposomal amphotericin B. The mean total dose was 35 mg/kg (range 24-50 mg/kg), which resulted in the healing of all the lesions in all patients and no recurrences were observed during the follow-up period (mean 25 months; range 7-40 months).
脂质体两性霉素 B 已被用作黏膜利什曼病的替代治疗方法，但最佳剂量尚未确定。我们回顾性分析了 8 例黏膜利什曼病患者接受脂质体两性霉素 B 治疗的临床结果。平均总剂量为 35mg/kg（范围 24-50mg/kg），所有患者的所有病变均治愈，随访期间无复发（平均 25 个月；范围 7-40 个月）。
