Moeller Emily, Blocker Tiffany, Esson Douglas, Madsen Richard
Eye Care for Animals, Tustin, CA, USA.
Vet Ophthalmol. 2011 Nov;14(6):385-94. doi: 10.1111/j.1463-5224.2011.00896.x. Epub 2011 Apr 19.
To evaluate the incidence and risk factors associated with development of postoperative glaucoma in the Labrador Retriever following routine phacoemulsification.
Medical records from Labradors and a randomly selected population of non-Labradors were retrospectively evaluated. Signalment, diabetic status, cataract stage, gonioscopic findings, presence of preoperative lens-induced uveitis, development of postoperative hypertension (POH), postoperative glaucoma and postoperative visual status were recorded for each patient. Survival curves were developed using the Cox proportional hazards model.
Forty-two Labradors (66 eyes) and 199 non-Labradors (314 eyes) were included. The incidence of POH was significantly higher in Labradors (33%) than non-Labradors (18%). Labradors were at significantly increased risk of postoperative glaucoma and blindness compared to non-Labradors. Estimated probabilities of postoperative glaucoma in Labradors were 23%, 25%, 30% and 35% at weeks 4, 26, 52 and 104, respectively, compared with 5%, 6%, 7% and 9% at weeks 4, 26, 52 and 104, respectively, in non-Labradors. Estimated probabilities of postoperative blindness in Labradors were 5%, 9%, 15% and 27% at weeks 4, 26, 52 and 104, respectively, compared with 2%, 3%, 5% and 10% at weeks 4, 26, 52 and 104, respectively, in non-Labradors. Risk factors for the development of glaucoma in Labradors included increasing age and development of POH. No statistically significant risk factors for the development of glaucoma were identified in non-Labradors.
Labradors are at increased risk of glaucoma and blindness following phacoemulsification compared with non-Labradors. POH and increasing age represent risk factors for the development of postoperative glaucoma in Labradors.
评估拉布拉多寻回犬在常规超声乳化术后发生青光眼的发生率及相关危险因素。
对拉布拉多犬和随机选取的非拉布拉多犬群体的病历进行回顾性评估。记录每只犬的信号、糖尿病状态、白内障分期、前房角镜检查结果、术前晶状体诱导性葡萄膜炎的存在情况、术后高血压（POH）的发生情况、术后青光眼及术后视力状况。使用Cox比例风险模型绘制生存曲线。
纳入42只拉布拉多犬（66只眼）和199只非拉布拉多犬（314只眼）。拉布拉多犬的POH发生率（33%）显著高于非拉布拉多犬（18%）。与非拉布拉多犬相比，拉布拉多犬术后发生青光眼和失明的风险显著增加。拉布拉多犬术后第4周、26周、52周和104周发生青光眼的估计概率分别为23%、25%、30%和35%，而非拉布拉多犬在相应时间点的概率分别为5%、6%、7%和9%。拉布拉多犬术后第4周、26周、52周和104周失明的估计概率分别为5%、9%、15%和27%，而非拉布拉多犬在相应时间点的概率分别为2%、3%、5%和10%。拉布拉多犬发生青光眼的危险因素包括年龄增长和POH的发生。在非拉布拉多犬中未发现与青光眼发生相关的具有统计学意义的危险因素。
与非拉布拉多犬相比，拉布拉多犬在超声乳化术后发生青光眼和失明的风险增加。POH和年龄增长是拉布拉多犬术后发生青光眼的危险因素。
