β-catenin is dynamically stored and cleared in multiple myeloma by the proteasome-aggresome-autophagosome-lysosome pathway.
作者信息
Sukhdeo K, Mani M, Hideshima T, Takada K, Pena-Cruz V, Mendez G, Ito S, Anderson K C, Carrasco D R
出版信息
Leukemia. 2012 May;26(5):1116-9. doi: 10.1038/leu.2011.303. Epub 2011 Nov 4.
Abstract
摘要
相似文献
1
β-catenin is dynamically stored and cleared in multiple myeloma by the proteasome-aggresome-autophagosome-lysosome pathway.
Leukemia. 2012 May;26(5):1116-9. doi: 10.1038/leu.2011.303. Epub 2011 Nov 4.
2
Zinc Protoporphyrin Suppresses β-Catenin Protein Expression in Human Cancer Cells: The Potential Involvement of Lysosome-Mediated Degradation.
PLoS One. 2015 May 22;10(5):e0127413. doi: 10.1371/journal.pone.0127413. eCollection 2015.
3
Ricolinostat (ACY-1215) induced inhibition of aggresome formation accelerates carfilzomib-induced multiple myeloma cell death.
Br J Haematol. 2015 May;169(3):423-34. doi: 10.1111/bjh.13315. Epub 2015 Feb 23.
4
Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress.
Int J Oncol. 2011 Mar;38(3):643-54. doi: 10.3892/ijo.2010.882. Epub 2010 Dec 21.
5
β-Catenin Inhibitor BC2059 Is Efficacious as Monotherapy or in Combination with Proteasome Inhibitor Bortezomib in Multiple Myeloma.
Mol Cancer Ther. 2017 Sep;16(9):1765-1778. doi: 10.1158/1535-7163.MCT-16-0624. Epub 2017 May 12.
6
Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib.
Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
7
Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application.
Leukemia. 2013 Dec;27(12):2397-403. doi: 10.1038/leu.2013.150. Epub 2013 May 14.
8
Farnesyl transferase inhibitors, autophagy, and proteasome inhibition: synergy for all the right reasons.
Autophagy. 2011 Apr;7(4):448-9. doi: 10.4161/auto.7.4.14683. Epub 2011 Apr 1.
9
Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells.
Oncogene. 2010 Jan 21;29(3):451-62. doi: 10.1038/onc.2009.343. Epub 2009 Nov 2.
10
Intracellular protein degradation and its therapeutic implications.
Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8530-3. doi: 10.1158/1078-0432.CCR-05-2305.
引用本文的文献
1
Label-free protein-structure-sensitive live-cell microscopy for patient-specific assessment of myeloma therapy.
Nat Biomed Eng. 2025 Jul 14. doi: 10.1038/s41551-025-01443-3.
2
A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer.
Sci Adv. 2022 Apr 29;8(17):eabm3108. doi: 10.1126/sciadv.abm3108.
3
Interplay Between Autophagy and Wnt/β-Catenin Signaling in Cancer: Therapeutic Potential Through Drug Repositioning.
Front Oncol. 2020 Aug 18;10:1037. doi: 10.3389/fonc.2020.01037. eCollection 2020.
4
Bioactive Compounds from . Alleviate the Progression of Multiple Myeloma in Mouse Model and Improve Bone Marrow Microenvironment.
Onco Targets Ther. 2020 Jan 31;13:959-973. doi: 10.2147/OTT.S235944. eCollection 2020.
5
Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers.
Front Oncol. 2020 Jan 17;9:1469. doi: 10.3389/fonc.2019.01469. eCollection 2019.
6
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.
Nat Commun. 2019 Dec 12;10(1):5681. doi: 10.1038/s41467-019-13475-w.
7
LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma.
Sci Rep. 2017 Aug 14;7(1):8022. doi: 10.1038/s41598-017-07403-5.
8
Role of Wnt/β-catenin pathway in inducing autophagy and apoptosis in multiple myeloma cells.
Oncol Lett. 2016 Dec;12(6):4623-4629. doi: 10.3892/ol.2016.5289. Epub 2016 Oct 18.
9
The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation.
Cell Cycle. 2016 Aug 17;15(16):2124-2134. doi: 10.1080/15384101.2016.1196306. Epub 2016 Jun 13.
10
Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells.
J Virol. 2015 Jul;89(13):6792-804. doi: 10.1128/JVI.00351-15. Epub 2015 Apr 22.
本文引用的文献
1
Initial genome sequencing and analysis of multiple myeloma.
Nature. 2011 Mar 24;471(7339):467-72. doi: 10.1038/nature09837.
2
Evidence of a role for activation of Wnt/beta-catenin signaling in the resistance of plasma cells to lenalidomide.
J Biol Chem. 2011 Apr 1;286(13):11009-20. doi: 10.1074/jbc.M110.180208. Epub 2010 Dec 28.
3
BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.
Cancer Res. 2009 Oct 1;69(19):7577-86. doi: 10.1158/0008-5472.CAN-09-0773. Epub 2009 Sep 8.
4
Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression.
Blood. 2009 Sep 24;114(13):2699-708. doi: 10.1182/blood-2008-12-194290. Epub 2009 Aug 3.
5
Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma.
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7516-21. doi: 10.1073/pnas.0610299104. Epub 2007 Apr 23.
6
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.
Cancer Cell. 2006 Apr;9(4):313-25. doi: 10.1016/j.ccr.2006.03.019.
7
Clinical implication of centrosome amplification in plasma cell neoplasm.
Blood. 2006 May 1;107(9):3669-75. doi: 10.1182/blood-2005-09-3810. Epub 2005 Dec 22.
8
The SCID-hu myeloma model.
Methods Mol Med. 2005;113:183-90. doi: 10.1385/1-59259-916-8:183.
9
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. doi: 10.1073/pnas.0503221102. Epub 2005 Jun 3.
10
Regulation of inducible nitric oxide synthase by aggresome formation.
Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4854-9. doi: 10.1073/pnas.0500485102. Epub 2005 Mar 21.
Zotero 插件