酶响应发光的头孢菌素钌(II)探针用于细胞内成像和光灭活抗生素耐药菌。
Enzyme responsive luminescent ruthenium(II) cephalosporin probe for intracellular imaging and photoinactivation of antibiotics resistant bacteria.
机构信息
Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore.
出版信息
Chem Commun (Camb). 2012 Feb 7;48(12):1739-41. doi: 10.1039/c1cc16165b. Epub 2011 Nov 7.
PMID:22057185
Abstract
The Főrster resonance energy transfer (FRET) based luminescent ruthenium(II) cephalosporin probe has been designed and synthesized, which can be selectively activated by endogenous β-lactamases and thus provided a localized and specific intracellular luminescence imaging and photoinactivation of drug resistant bacterial pathogens.
摘要
基于Förster 共振能量转移（FRET）的发光头孢菌素钌（II）探针已被设计和合成，该探针可以被内源性β-内酰胺酶选择性激活，从而提供了一种局部和特定的细胞内发光成像和光灭活耐药细菌病原体的方法。
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