Eberts Matthew D, Vissotto de Paiva Diniz Pedro Paulo, Beall Melissa J, Stillman Brett A, Chandrashekar Ramaswamy, Breitschwerdt Edward B
Lakeland Veterinary Hospital, Baxter, MN, USA.
J Am Anim Hosp Assoc. 2011 Nov-Dec;47(6):e86-94. doi: 10.5326/JAAHA-MS-5578.
Eighteen clinically ill dogs, naturally infected with Anaplasma phagocytophilum, were examined at a veterinary practice in Baxter, Minnesota. A clinical examination, complete blood cell count, enzyme- linked immunosorbent assay (ELISA) for A phagocytophilum, Borrelia burgdorferi, and Ehrlichia canis antibodies and Dirofilaria immitis antigen, and a polymerase chain reaction test for A phagocytophilum DNA were obtained for all dogs. Physical examination findings included fever, arthropathy, lymphadenopathy, epistaxis, acute gastritis, cervical hyperpathia, and central nervous system dysfunction. Complete blood cell count abnormalities included thrombocytopenia, morulae in neutrophils, anemia, leukopenia, eosinopenia, lymphopenia, and monocytosis. Seroreactivity to A phagocytophilum was found in 61%, B burgdorferi antibodies in 17%, and D immitis antigen in 5% of the dogs. Fever, arthropathy, neurologic dysfunction, and epistaxis are clinical syndromes that can be associated with A phagocytophilum infection. Treatment with doxycycline resulted in rapid resolution of clinical signs in all dogs.
在明尼苏达州巴克斯特的一家兽医诊所，对18只自然感染嗜吞噬细胞无形体的临床患病犬进行了检查。对所有犬进行了临床检查、全血细胞计数、针对嗜吞噬细胞无形体、伯氏疏螺旋体、犬埃立希体抗体和犬恶丝虫抗原的酶联免疫吸附测定（ELISA），以及针对嗜吞噬细胞无形体DNA的聚合酶链反应检测。体格检查结果包括发热、关节病、淋巴结病、鼻出血、急性胃炎、颈部感觉过敏和中枢神经系统功能障碍。全血细胞计数异常包括血小板减少、中性粒细胞内出现桑葚体、贫血、白细胞减少、嗜酸性粒细胞减少、淋巴细胞减少和单核细胞增多。61%的犬对嗜吞噬细胞无形体呈血清反应阳性，17%的犬有伯氏疏螺旋体抗体，5%的犬有犬恶丝虫抗原。发热、关节病、神经功能障碍和鼻出血是可与嗜吞噬细胞无形体感染相关的临床综合征。用强力霉素治疗使所有犬的临床症状迅速缓解。
