Department of Psychology, Arizona State University, Tempe, AZ 85287-1104, USA.
Dev Psychol. 2012 May;48(3):740-54. doi: 10.1037/a0025938. Epub 2011 Nov 7.
The LPR and STin2 polymorphisms of the serotonin transporter gene (SLC6A4) were combined into haplotypes that, together with quality of maternal parenting, were used to predict initial levels and linear change in children's (N = 138) noncompliance and aggression from age 18-54 months. Quality of mothers' parenting behavior was observed when children were 18 months old, and nonparental caregivers' reports of noncompliance and aggression were collected annually from 18 to 54 months of age. Quality of early parenting was negatively related to the slope of noncompliance only for children with the LPR-S/STin2-10 haplotype and to 18-month noncompliance only for children with haplotypes that did not include LPR-S. The findings support the notion that SLC6A4 haplotypes index differential susceptibility to variability in parenting quality, with certain haplotypes showing greater reactivity to both supportive and unsupportive environments. These different genetic backgrounds likely reflect an evolutionary response to variation in the parenting environment.
5-羟色胺转运体基因（SLC6A4）的 LPR 和 STin2 多态性被组合成单体型，这些单体型与母亲养育质量一起，用于预测儿童（N=138）从 18 个月到 54 个月时不遵守规定和攻击行为的初始水平和线性变化。在儿童 18 个月大时观察母亲养育行为的质量，从 18 个月到 54 个月，每年收集非父母照顾者对不遵守规定和攻击行为的报告。早期养育质量与 LPR-S/STin2-10 单体型儿童的不遵守规定斜率呈负相关，仅与不包括 LPR-S 的单体型儿童的 18 个月不遵守规定呈负相关。研究结果支持这样一种观点，即 SLC6A4 单体型指数对养育质量变化的易感性存在差异，某些单体型对支持性和非支持性环境的反应更为强烈。这些不同的遗传背景可能反映了对养育环境变化的进化反应。
