Lozano R, Chalew S A, Kowarski A A
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201.
Am J Clin Nutr. 1990 Oct;52(4):667-70. doi: 10.1093/ajcn/52.4.667.
In susceptible individuals ingestion of glucose can lead to clinical symptoms of hypoglycemia as well as a reflex rise of counterregulatory hormones. We hypothesized that cornstarch, a slowly absorbed starch, might prevent hypoglycemic-symptom episodes. Eight patients who had characteristic signs, symptoms, and reflex hormonal responses of hypoglycemia at the glucose nadir after ingesting 75 g glucose (OGTT) participated. Patients ingested 75 g glucose followed by 75 g raw cornstarch (OGTT + CS). None of the patients reported symptoms or had signs of hypoglycemia in response to OGTT + CS. The glucose nadir concentration during OGTT + CS (3.8 +/- 0.6 mmol/L) was significantly higher than during OGTT (3.2 +/- 0.6; P less than 0.03). The responses of cortisol (331 +/- 166 nmol) and epinephrine (491 +/- 589 pmol/L) at the glucose nadir during OGTT + CS were significantly lower than the responses of cortisol (524 +/- 193 nmol/L; P less than 0.003) and epinephrine 1834 +/- 1135 pmol/L (P less than 0.0005) during OGTT. A slowly absorbed starch such as cornstarch may be an effective component in dietary management of this disorder.
在易感个体中，摄入葡萄糖可导致低血糖的临床症状以及反调节激素的反射性升高。我们推测，玉米淀粉这种吸收缓慢的淀粉，可能会预防低血糖症状发作。八名患者参与了研究，他们在摄入75克葡萄糖（口服葡萄糖耐量试验，OGTT）后血糖最低点时具有低血糖的典型体征、症状和反射性激素反应。患者先摄入75克葡萄糖，随后摄入75克生玉米淀粉（OGTT + CS）。没有患者报告有症状或出现OGTT + CS引起的低血糖体征。OGTT + CS期间的血糖最低点浓度（3.8 +/- 0.6毫摩尔/升）显著高于OGTT期间（3.2 +/- 0.6；P < 0.03）。OGTT + CS期间血糖最低点时皮质醇（331 +/- 166纳摩尔）和肾上腺素（491 +/- 589皮摩尔/升）的反应显著低于OGTT期间皮质醇（524 +/- 193纳摩尔/升；P < 0.003）和肾上腺素（1834 +/- 1135皮摩尔/升；P < 0.0005）的反应。像玉米淀粉这样吸收缓慢的淀粉可能是这种疾病饮食管理中的一种有效成分。
