Sheikhha Mohammad Hasan, Eftekhar Maryam, Kalantar Seyed Mehdi
Department of Genetics, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
J Hum Reprod Sci. 2011 May;4(2):86-90. doi: 10.4103/0974-1208.86089.
The aim of the study was to investigate the association between follicle-stimulating hormone receptor (FSHR) gene polymorphism at Position 680 and the outcomes of controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer (IVF-ET) in infertile women.
One hundred and eight patients under 35 years of age who underwent IVF-ET procedures were included in this study. The hormonal profile and treatment of all patients were analyzed and FSHR polymorphism was examined by polymerase chain reaction-restriction fragment length polymorphism. Women from all groups were classified based on polymorphisms at Position 680, occupied either by asparagines (Asn) or serine (Ser) as Asn/Asn, Asn/Ser, and Ser/Ser genotype.
Our study showed that all patients in the Asn/Asn group were normal responders and in the Asn/Ser group 64.8% were normal responders and 21.1% and 14.1% were poor and hyper responders respectively. In the Ser/Ser group we did not have normal responders and 46.7% of these patients were poor responders and 53.3% were hyper responders.
FSH receptor polymorphism is correlated with response to ovarian stimulation.
本研究旨在探讨680位点处促卵泡激素受体（FSHR）基因多态性与不孕女性体外受精-胚胎移植（IVF-ET）控制性卵巢刺激结局之间的关联。
本研究纳入了108例年龄在35岁以下接受IVF-ET手术的患者。分析了所有患者的激素水平和治疗情况，并通过聚合酶链反应-限制性片段长度多态性检测FSHR基因多态性。根据680位点处的多态性将所有组别的女性进行分类，该位点由天冬酰胺（Asn）或丝氨酸（Ser）占据，分为Asn/Asn、Asn/Ser和Ser/Ser基因型。
我们的研究表明，Asn/Asn组的所有患者均为正常反应者，Asn/Ser组中64.8%为正常反应者，21.1%和14.1%分别为低反应者和高反应者。在Ser/Ser组中，没有正常反应者，46.7%的患者为低反应者，53.3%为高反应者。
FSH受体多态性与卵巢刺激反应相关。
