Troudi Afef, Soudani Nejla, Amara Ibtissem Ben, Bouaziz Hanen, Ayadi Fatma Makni, Zeghal Najiba
Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia.
Toxicol Ind Health. 2012 Oct;28(9):820-30. doi: 10.1177/0748233711425068. Epub 2011 Nov 7.
Gibberellic acid (GA(3)) is a plant growth regulator used in agriculture worldwide. The present study investigated the propensity of GA(3) to induce hematological disorders. Pregnant Wistar rats were randomly divided into two groups: group I served as controls; group II received orally GA(3) (200 ppm) from the 14th day of pregnancy until day 14 after delivery. GA(3) reduced the number of red blood cells, hemoglobin concentration, and hematocrit in suckling rats, while these parameters remained unchanged in their mothers. White blood cells increased in mothers and were unchanged in their pups. Several studies have associated these hematological disorders with oxidative stress. In fact, GA(3) treatment revealed in erythrocytes a significant increase in malondialdehyde levels and a decrease in antioxidant enzyme activities such as superoxide dismutase, catalase, and glutathione peroxidase. Moreover, a significant decline was observed in acetylcholinesterase activity, glutathione, nonprotein thiols, and vitamin C levels.
赤霉酸（GA(3)）是一种在全球农业中使用的植物生长调节剂。本研究调查了GA(3)诱发血液系统疾病的倾向。将怀孕的Wistar大鼠随机分为两组：第一组作为对照组；第二组从怀孕第14天到产后第14天口服GA(3)（200 ppm）。GA(3)降低了哺乳大鼠的红细胞数量、血红蛋白浓度和血细胞比容，而这些参数在其母亲中保持不变。母亲的白细胞增加，而幼崽的白细胞没有变化。几项研究将这些血液系统疾病与氧化应激联系起来。事实上，GA(3)处理显示红细胞中丙二醛水平显著增加，超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶等抗氧化酶活性降低。此外，乙酰胆碱酯酶活性、谷胱甘肽、非蛋白硫醇和维生素C水平显著下降。
