Seder J D, Burke J F, Pauletto F J
Cardiovascular Division, Lankenau Hospital, Philadelphia, PA 19151.
J Am Soc Echocardiogr. 1990 Jul-Aug;3(4):316-9. doi: 10.1016/s0894-7317(14)80315-5.
To determine whether there is a correlation between aortic root size and the prevalence of aortic regurgitation, we performed color flow Doppler echocardiographic studies on 1015 consecutive patients during a 3-month period. Patients were grouped according to their M-mode aortic root diameter as measured in the left parasternal position. The measured groups ranged from 2.0 to 4.5 cm, grouped at 0.1 cm intervals. As the aortic root size enlarged, the prevalence of aortic regurgitation increased linearly (p less than 0.001; correlation coefficient, r = 0.75). At an aortic root size in the "small normal" range of 2.0 to 2.4 cm, the prevalence of aortic regurgitation was 0% to 15%. In the "intermediate" and "top normal" ranges of 2.9 to 3.7 cm, the prevalence of aortic regurgitation increased linearly from 15% to 47%. With aortic root dilation, the prevalence of aortic root regurgitation was generally more than 50%. The severity of aortic regurgitation was semiquantified. Aortic root size was not a good indicator for the severity of aortic regurgitation. Patients with moderate and severe aortic regurgitation had variable aortic root sizes. Throughout the range of aortic root sizes, mild aortic regurgitation predominated. We conclude that aortic regurgitation is a common finding in patients with aortic roots that are dilated or are in the "top normal" size range, that the prevalence of aortic regurgitation increases linearly with aortic root size, and that aortic root size does not correlate with the severity of aortic regurgitation.
为了确定主动脉根部大小与主动脉瓣反流患病率之间是否存在相关性，我们在3个月期间对1015例连续患者进行了彩色多普勒超声心动图研究。根据在左胸骨旁位置测量的M型主动脉根部直径对患者进行分组。测量的组范围为2.0至4.5 cm，以0.1 cm间隔分组。随着主动脉根部大小增大，主动脉瓣反流的患病率呈线性增加（p小于0.001；相关系数，r = 0.75）。在主动脉根部大小处于“小正常”范围2.0至2.4 cm时，主动脉瓣反流的患病率为0%至15%。在2.9至3.7 cm的“中等”和“高正常”范围内，主动脉瓣反流的患病率从15%线性增加至47%。随着主动脉根部扩张，主动脉根部反流的患病率通常超过50%。对主动脉瓣反流的严重程度进行了半定量。主动脉根部大小不是主动脉瓣反流严重程度的良好指标。中度和重度主动脉瓣反流患者的主动脉根部大小各不相同。在整个主动脉根部大小范围内，轻度主动脉瓣反流占主导。我们得出结论，主动脉瓣反流在主动脉根部扩张或处于“高正常”大小范围的患者中是常见发现，主动脉瓣反流的患病率随主动脉根部大小呈线性增加，并且主动脉根部大小与主动脉瓣反流的严重程度无关。
