Hashimoto Y, Oniki T, Aerbajinai W, Numano F
Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
Heart Vessels Suppl. 1992;7:111-5. doi: 10.1007/BF01744555.
To characterize aortic regurgitation in patients with Takayasu arteritis, we studied 48 females with arteritis (mean age 47 +/- 12 years) by means of color Doppler echocardiography. Aortic regurgitation was confirmed in 32 out of 48 patients (67%) by color-flow mapping. Twenty-four patients had mild or no aortic regurgitation (group A), 9 had moderate (group B), and 15 had severe (group C) aortic regurgitation. We compared the echocardiographic data obtained from patients with Takayasu arteritis with those of 14 normal controls and 9 patients with severe aortic regurgitation of valvular origins (group V). The aortic root diameter (AOD) in group B (23 +/- 4 mm/M2) and group C (22 +/- 3 mm/M2) revealed a statistically significant large value as compared with that in group A (18 +/- 2 mm/M2) and normal controls (17 +/- 3 mm/M2). However, the differences, between groups B and C and groups C and V, were not significant. The AOD was not obviously dilated in a considerable number of group C patients. Aortic valve involvement was seen in several group C patients and moderate concentric left ventricular hypertrophy was present in all group C patients. Group C patients therefore, have concentric left ventricular hypertrophy but may or may not have dilatation of the aortic root which can be detected on echocardiography. We conclude that aortic valve involvement may cause aortic regurgitation in some patients with Takayasu arteritis and that aortic regurgitation is more common than previously believed.
为了明确大动脉炎患者的主动脉反流情况，我们通过彩色多普勒超声心动图对48例动脉炎女性患者（平均年龄47±12岁）进行了研究。通过彩色血流图检查，48例患者中有32例（67%）确诊存在主动脉反流。24例患者有轻度主动脉反流或无主动脉反流（A组），9例有中度主动脉反流（B组），15例有重度主动脉反流（C组）。我们将大动脉炎患者的超声心动图数据与14例正常对照者以及9例瓣膜性重度主动脉反流患者（V组）的数据进行了比较。与A组（18±2mm/M2）和正常对照者（17±3mm/M2）相比，B组（23±4mm/M2）和C组（22±3mm/M2）的主动脉根部直径（AOD）在统计学上显示出显著更大的值。然而，B组与C组之间以及C组与V组之间的差异并不显著。相当数量的C组患者中，主动脉根部并未明显扩张。部分C组患者可见主动脉瓣受累，所有C组患者均存在中度同心性左心室肥厚。因此，C组患者存在同心性左心室肥厚，但主动脉根部可能扩张也可能未扩张，这可通过超声心动图检测到。我们得出结论，在一些大动脉炎患者中，主动脉瓣受累可能导致主动脉反流，且主动脉反流比之前认为的更为常见。
