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Int J Mol Sci. 2022 Mar 30;23(7):3787. doi: 10.3390/ijms23073787.
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Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection Activation of Immunoproteasome.益智仁A通过激活免疫蛋白酶体促进α-突触核蛋白降解以实现神经保护
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Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29.蛋白酶体亚基 α7 的 C 末端尾部磷酸化对于蛋白酶体质量控制因子 Ecm29 的结合是必需的。
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Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.通过激活环磷酸腺苷-蛋白激酶A信号通路，可在疾病早期预防tau蛋白驱动的26S蛋白酶体损伤和认知功能障碍。
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本文引用的文献

1
UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.UBLCP1 是一种 26S 蛋白酶体磷酸酶，可调节核蛋白酶体活性。
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18649-54. doi: 10.1073/pnas.1113170108. Epub 2011 Sep 26.
2
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.ATP 以成对的形式与蛋白酶体 ATP 酶结合，具有不同的功能效应，这意味着存在一个有序的反应循环。
Cell. 2011 Feb 18;144(4):526-38. doi: 10.1016/j.cell.2011.02.005.
3
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.亚纳米分辨率下的裂殖酵母 26S 蛋白酶体结构。
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20992-7. doi: 10.1073/pnas.1015530107. Epub 2010 Nov 22.
4
ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation.ATP 依赖的泛素缀合物与 26S 蛋白酶体结合的步骤，这些步骤决定了降解的命运。
Mol Cell. 2010 Nov 24;40(4):671-81. doi: 10.1016/j.molcel.2010.11.002.
5
Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome.RPN10 的单泛素化调节底物向蛋白酶体的招募。
Mol Cell. 2010 Jun 11;38(5):733-45. doi: 10.1016/j.molcel.2010.05.001.
6
Co- and post-translational modifications of the 26S proteasome in yeast.酵母中 26S 蛋白酶体的共翻译和翻译后修饰。
Proteomics. 2010 Aug;10(15):2769-79. doi: 10.1002/pmic.200900283.
7
Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines.自磷酸化的 CaMKIIalpha 作为支架将蛋白酶体募集到树突棘。
Cell. 2010 Feb 19;140(4):567-78. doi: 10.1016/j.cell.2010.01.024.
8
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening.泛素化蛋白通过结合 Usp14/Ubp6 激活蛋白酶体，导致 20S 门打开。
Mol Cell. 2009 Dec 11;36(5):794-804. doi: 10.1016/j.molcel.2009.11.015.
9
Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II.神经元活动及钙/钙调蛋白依赖性蛋白激酶II对蛋白酶体的调控
J Biol Chem. 2009 Sep 25;284(39):26655-65. doi: 10.1074/jbc.M109.021956. Epub 2009 Jul 28.
10
Recognition and processing of ubiquitin-protein conjugates by the proteasome.蛋白酶体对泛素-蛋白质缀合物的识别与加工。
Annu Rev Biochem. 2009;78:477-513. doi: 10.1146/annurev.biochem.78.081507.101607.

Keeping proteasomes under control--a role for phosphorylation in the nucleus.

作者信息

Sha Zhe, Peth Andreas, Goldberg Alfred L

机构信息

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18573-4. doi: 10.1073/pnas.1115315108. Epub 2011 Nov 7.

DOI:10.1073/pnas.1115315108
PMID:22065770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3219122/
Abstract
摘要