Biologicals Science and Technology, Ipsen Biopharm Limited, Ash Road North, Wrexham, LL13 9UF, UK.
Toxins (Basel). 2011 Jan;3(1):63-81. doi: 10.3390/toxins3010063. Epub 2011 Jan 12.
The uses of botulinum toxin in the fields of neurology, ophthalmology, urology, rehabilitation medicine and aesthetic applications have been revolutionary for the treatment of patients. This non-invasive therapeutic has continually been developed since first discovered in the 1970s as a new approach to what were previously surgical treatments. As these applications develop, so also the molecules are developing into tools with new therapeutic properties in specific clinical areas. This review examines how the botulinum toxin molecule is being adapted to new therapeutic uses and also how new areas of use for the existing molecules are being identified. Prospects for future developments are also considered.
肉毒毒素在神经科、眼科、泌尿科、康复医学和美容应用领域的应用，为患者的治疗带来了革命性的变化。自 20 世纪 70 年代首次发现以来，这种非侵入性治疗方法不断发展，成为以前手术治疗的新方法。随着这些应用的发展，肉毒毒素分子也在不断发展，成为具有特定临床领域新治疗特性的工具。本文综述了肉毒毒素分子如何适应新的治疗用途，以及如何发现现有分子的新用途。还考虑了未来发展的前景。
