College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Mar Drugs. 2019 Aug 21;17(9):487. doi: 10.3390/md17090487.
Fucoidan is a polysaccharide largely made up of l-fucose and sulfate groups. Fucoidan is favorable worldwide, especially amongst the food and pharmaceutical industry as a consequence of its promising therapeutic effects. Its applaudable biological functions are ascribed to its unique biological structure. Classical bioactivities associated with fucoidan include anti-oxidant, anti-tumor, anti-coagulant, anti-thrombotic, immunoregulatory, anti-viral and anti-inflammatory effects. More recently, a variety of in vitro and in vivo studies have been carried out to further highlight its therapeutic potentials. This review focuses on the progress towards understanding fucoidan and its biological activities, which may be beneficial as a future therapy. Hence, we have summarized in vitro and in vivo studies that were done within the current decade. We expect this review and a variety of others can contribute as a theoretical basis for understanding and inspire further product development of fucoidan.
褐藻糖胶是一种主要由 L-岩藻糖和硫酸基团组成的多糖。褐藻糖胶在世界范围内都受到欢迎,尤其是在食品和制药行业,因为它具有有前景的治疗效果。其令人称赞的生物功能归因于其独特的生物结构。与褐藻糖胶相关的经典生物活性包括抗氧化、抗肿瘤、抗凝血、抗血栓、免疫调节、抗病毒和抗炎作用。最近,已经进行了各种体外和体内研究,以进一步强调其治疗潜力。本综述重点介绍了对褐藻糖胶及其生物学活性的理解进展,这可能作为未来的一种治疗方法有益。因此,我们总结了在当前十年内进行的体外和体内研究。我们期望本综述和其他各种综述可以作为理解和启发褐藻糖胶进一步产品开发的理论基础。