碱性磷酸酶升高与食用含褐藻和蘑菇提取物的补充剂有关。
Increased Alkaline Phosphatase Associated with Brown Algae and Mushroom Extract-Containing Supplement Use.
作者信息
Perera Himain, McCudden Christopher, Cooper Curtis L
机构信息
Ottawa Hospital Research Institute, 501 Smyth Box 511, Ottawa, ON K1H8L6, Canada.
University of Ottawa, Marie-Curie Private, Ottawa, ON K1N 9A4, Canada.
出版信息
Can Liver J. 2025 Mar 5;8(2):290-294. doi: 10.3138/canlivj-2025-0005. eCollection 2025 May.
BACKGROUND
Marked alkaline phosphatase (ALP) elevation as a consequence of drug exposure is uncommon. We report a chronic hepatitis B virus (HBV) positive 47-year-old male patient taking a brown algae and mushroom extract-containing supplement (Umi No Shizuku) with ALP levels almost 7 times the upper limit during routine bloodwork. ALP was 991 U/L (normal 50-112 U/L). All other liver studies were within normal range: alanine aminotransferase (ALT) 32 U/L (normal 10-63 U/L), aspartate aminotransferase (AST) 25 U/L (normal 12-41 U/L), gamma-glutamyl transferase (GGT) 22 U/L (normal 11-105 U/L), and total bilirubin 13 µmol/L (normal ≤ 13 µmol/L).
METHODS
Serial bloodwork was conducted to assess liver studies and bone disease markers. Imaging was utilized to exclude liver and bone disease.
RESULTS
Bloodwork and imaging all returned values within the normal range. Interrupting the supplement led to rapid normalization of ALP blood levels in the patient.
CONCLUSIONS
The supplement was the only variable changed in this case, leading us to suspect that it was responsible for the elevated ALP levels.
背景
药物暴露导致显著碱性磷酸酶（ALP）升高并不常见。我们报告了一名47岁慢性乙型肝炎病毒（HBV）阳性男性患者，在常规血液检查中，其服用含褐藻和蘑菇提取物的补充剂（Umi No Shizuku）后，ALP水平几乎是上限的7倍。ALP为991 U/L（正常范围50 - 112 U/L）。所有其他肝脏检查指标均在正常范围内：丙氨酸氨基转移酶（ALT）32 U/L（正常范围10 - 63 U/L），天冬氨酸氨基转移酶（AST）25 U/L（正常范围12 - 41 U/L），γ-谷氨酰转移酶（GGT）22 U/L（正常范围11 - 105 U/L），总胆红素13 µmol/L（正常范围≤13 µmol/L）。
方法
进行系列血液检查以评估肝脏检查指标和骨病标志物。利用影像学检查排除肝脏和骨病。
结果
血液检查和影像学检查结果均在正常范围内。停用该补充剂后，患者ALP血液水平迅速恢复正常。
结论
在该病例中，补充剂是唯一改变的变量，这使我们怀疑它是导致ALP水平升高的原因。
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