Santini Emanuela, Klann Eric
Center for Neural Science, New York University New York, NY, USA.
Front Behav Neurosci. 2011 Nov 8;5:76. doi: 10.3389/fnbeh.2011.00076. eCollection 2011.
In the last decade, a plethora of studies utilizing pharmacological, biochemical, and genetic approaches have shown that precise translational control is required for long-lasting synaptic plasticity and the formation of long-term memory. Moreover, more recent studies indicate that alterations in translational control are a common pathophysiological feature of human neurological disorders, including developmental disorders, neuropsychiatric disorders, and neurodegenerative diseases. Finally, translational control mechanisms are susceptible to modification by psychoactive drugs. Taken together, these findings point to a central role for translational control in the regulation of synaptic function and behavior.
在过去十年中，大量利用药理学、生物化学和遗传学方法进行的研究表明，精确的翻译控制对于持久的突触可塑性和长期记忆的形成是必需的。此外，最近的研究表明，翻译控制的改变是人类神经疾病（包括发育障碍、神经精神疾病和神经退行性疾病）常见的病理生理特征。最后，翻译控制机制易受精神活性药物的影响。综上所述，这些发现表明翻译控制在突触功能和行为调节中起着核心作用。
