Institut de Biologie du Développement de Marseille-Luminy, UMR6216 CNRS et Aix-Marseille Universites, Parc Scientifique de Luminy, Marseille, France.
Nat Rev Immunol. 2011 Nov 11;11(12):837-51. doi: 10.1038/nri3089.
All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules - the peptidoglycan recognition proteins - has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.
所有动物，包括人类，都与微生物共生。免疫系统容纳微生物组的定植，维持微生物组-宿主的平衡，并抵御病原体。这篇综述分析了抗菌模式识别分子家族——肽聚糖识别蛋白——如何进化出各种迷人的机制来控制宿主与共生、共生和寄生微生物的相互作用，使无脊椎动物和脊椎动物宿主都受益。
