Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Arch Pharm Res. 2011 Oct;34(10):1633-7. doi: 10.1007/s12272-011-1007-1. Epub 2011 Nov 12.
A new β-resorcylic macrolide, 5'-hydroxyzearalenone (1), and six known β-resorcylic macrolides were isolated from the seagrass-derived fungus Fusarium sp. PSU-ES73. Their structures were established by analysis of spectral data. All of the isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, both standard and methicillin-resistant strains, as well as their antifungal activity against Cryptococcus neoformans. Only the known compound zearalenone (2) displayed weak antibacterial and antifungal activities.
从海洋草衍生真菌 Fusarium sp. PSU-ES73 中分离得到一种新的β-Resorcylic 大环内酯化合物 5'-羟基玉米赤霉烯酮（1）和六种已知的β-Resorcylic 大环内酯化合物。通过光谱数据分析确定了它们的结构。所有分离得到的化合物都进行了抗菌活性评估，包括对金黄色葡萄球菌（包括标准菌株和耐甲氧西林菌株）和新型隐球菌的抗菌活性。只有已知化合物玉米赤霉烯酮（2）显示出较弱的抗菌和抗真菌活性。
