Department of Chemistry, Pukyong National University, Busan, Korea.
J Nat Prod. 2010 Dec 27;73(12):2061-3. doi: 10.1021/np1005289. Epub 2010 Nov 22.
The addition of CaBr(2) to the fermentation of a marine-derived Fusarium tricinctum resulted in production of halogenated chlamydosporol analogues. Two new antimicrobial halogenated pyranopyranones, bromomethylchlamydosporols A (1) and B (2), and two known compounds, chlamydosporol (an inseparable epimeric mixture of 7R:7S = 1:1 from (1)H NMR data) (3) and fusarielin A (4), were isolated from the culture. The structures of 1 and 2 were assigned through a combination of spectroscopic data analyses. Compounds 1-4 exhibited mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC values of each strain were as follows: compounds 1 and 2 showed an MIC of 15.6 μg/mL against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus, and compounds 3 and 4 exhibited an MIC of 31.5 μg/mL against S. aureus and methicillin-resistant S. aureus and 62.5 μg/mL against multidrug-resistant S. aureus.
添加 CaBr(2) 到海洋来源的镰孢菌属 Fusarium tricinctum 的发酵中，导致产生卤代 chlamydosporol 类似物。两种新的抗微生物卤代吡喃酮，溴甲基 chlamydosporols A（1）和 B（2），以及两种已知化合物，chlamydosporol（（1）H NMR 数据中为 7R:7S = 1:1 的不可分离的表异构混合物）（3）和 fusarielin A（4），从培养物中分离得到。通过光谱数据分析的组合，确定了 1 和 2 的结构。化合物 1-4 对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和多药耐药金黄色葡萄球菌表现出温和的抗菌活性。每种菌株的 MIC 值如下：化合物 1 和 2 对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和多药耐药金黄色葡萄球菌的 MIC 值均为 15.6 μg/mL，化合物 3 和 4 对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌的 MIC 值均为 31.5 μg/mL，对多药耐药金黄色葡萄球菌的 MIC 值为 62.5 μg/mL。
