Medical University of Vienna, Center for Brain Research, Department of Neurophysiology, Spitalgasse 4, A-1090 Vienna, Austria.
Curr Opin Pharmacol. 2012 Feb;12(1):18-27. doi: 10.1016/j.coph.2011.10.018. Epub 2011 Nov 9.
Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle features with hyperalgesia including induction protocols, pharmacological profile, neuronal and glial cell types involved and means for prevention. LTP at synapses of nociceptive nerve fibres constitutes a contemporary cellular model for pain amplification following trauma, inflammation, nerve injury or withdrawal from opioids. It provides a novel target for pain therapy. This review summarizes recent progress which has been made in unravelling the properties and functions of LTP in the nociceptive system and in identifying means for its prevention and reversal.
痛觉通路上突触强度的长期增强（LTP）与痛觉过敏具有共同的主要特征，包括诱导方案、药理学特征、涉及的神经元和神经胶质细胞类型以及预防措施。伤害性神经纤维突触的 LTP 构成了创伤、炎症、神经损伤或阿片类药物戒断后疼痛放大的当代细胞模型。它为疼痛治疗提供了一个新的靶点。这篇综述总结了最近在阐明痛觉系统中 LTP 的特性和功能以及确定其预防和逆转方法方面取得的进展。
