Schoenberg J B, Klotz J B, Wilcox H B, Nicholls G P, Gil-del-Real M T, Stemhagen A, Mason T J
New Jersey State Department of Health, Trenton 08625.
Cancer Res. 1990 Oct 15;50(20):6520-4.
To evaluate the association of indoor radon exposure with lung cancer risk, yearlong alpha track detector measurements of radon were conducted in dwellings which had been occupied for at least 10 years by 433 New Jersey female lung cancer cases and 402 controls who were subjects in a larger population-based study. Adjusted odds ratios were 1.1 (90% confidence interval, 0.79-1.7), 1.3 (90% confidence interval, 0.62-2.9), and 4.2 (90% confidence interval, 0.99-17.5) for exposures of 1.0-1.9, 2.0-3.9, and 4.0-11.3 pCi/liter, respectively, relative to exposures of less than 1.0 pCi/liter, showing a significant trend (1-sided P = 0.04) with increasing radon concentration. The trend was strongest among light smokers (less than 15 cigarettes/day, 1-sided P = 0.01). The trend for lung cancer risk with estimated cumulative radon exposure was slightly weaker (1-sided P = 0.09). The increase in relative risk for each unit of cumulative exposure, 3.4% (90% confidence interval 0.0-8.0%) per working level month, was consistent with the range of 0.5-4.0% per working level month generally reported for underground miner studies, supporting the extrapolation of the occupational data to the residential setting. However, the possibility of selection biases, the small number of high exposures, and other uncertainties necessitate caution in interpretation of these data.
为评估室内氡暴露与肺癌风险之间的关联，在新泽西州433例女性肺癌病例和402名对照的住所中进行了为期一年的氡α径迹探测器测量，这些病例和对照来自一项更大规模的基于人群的研究，其住所已居住至少10年。相对于暴露水平低于1.0皮居里/升，暴露水平为1.0 - 1.9、2.0 - 3.9和4.0 - 11.3皮居里/升时的调整优势比分别为1.1（90%置信区间，0.79 - 1.7）、1.3（90%置信区间，0.62 - 2.9）和4.2（90%置信区间，0.99 - 17.5），显示出随着氡浓度增加的显著趋势（单侧P = 0.04）。该趋势在轻度吸烟者（每天少于15支香烟）中最为明显（单侧P = 0.01）。肺癌风险与估计的累积氡暴露的趋势略弱（单侧P = 0.09）。每工作水平月累积暴露每增加一个单位，相对风险增加3.4%（90%置信区间0.0 - 8.0%），这与地下矿工研究中通常报告的每工作水平月0.5 - 4.0%的范围一致，支持将职业数据外推至居住环境。然而，由于存在选择偏倚的可能性、高暴露病例数量较少以及其他不确定性，在解释这些数据时需要谨慎。
