流感神经氨酸酶。
Influenza neuraminidase.
机构信息
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
出版信息
Influenza Other Respir Viruses. 2012 Jul;6(4):245-56. doi: 10.1111/j.1750-2659.2011.00304.x. Epub 2011 Nov 16.
Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of neuraminidase in the subunit vaccine gives increased protection. This article describes current knowledge on the structure, enzyme activity, and antigenic significance of neuraminidase.
流感神经氨酸酶是两种已获许可的抗病毒药物的靶点，这两种药物都非常成功，还有更多药物正在开发中。然而，尽管有证据表明将神经氨酸酶纳入亚单位疫苗可提供更高的保护，但神经氨酸酶作为疫苗靶点在很大程度上仍被忽视。本文描述了神经氨酸酶的结构、酶活性和抗原意义的现有知识。
Zotero 插件