Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, North Carolina 27709-2194, USA.
Ann N Y Acad Sci. 2012 Feb;1248:18-38. doi: 10.1111/j.1749-6632.2011.06199.x. Epub 2011 Nov 17.
There are numerous medicinal chemistry reports in the literature describing the pharmacological properties of thousands of narcotics, stimulants, hallucinogens, sedative-hypnotic drugs, cannabinoids, and other psychoactive substances as well as synthetic methods for their preparations. This information, while essential for the advancement of science, has been used by clandestine chemists to manufacture and market an endless variety of analogs of so-called designer drugs. In this review, we describe how clandestine chemists used the principles of medicinal chemistry to design molecules, referred to as designer drugs, that elicit the effects of opioids, amphetamine and analogs, cannabinoids, and phencyclidine analogs while circumventing the law.
文献中有大量的药物化学报告，描述了数千种麻醉品、兴奋剂、致幻剂、镇静催眠药、大麻素和其他精神活性物质的药理学特性，以及它们的制备方法。这些信息对于科学的发展是必不可少的，但却被秘密化学家用来制造和销售所谓的“设计药物”的各种类似物。在这篇综述中，我们描述了秘密化学家如何利用药物化学原理来设计分子，这些分子被称为“设计药物”，它们能引发阿片类药物、苯丙胺及其类似物、大麻素和苯环己哌啶类似物的作用，同时规避法律。
