Graduate Periodontology, Faculty of Odontology, University Complutense of Madrid and Branemark Osseointegration Center, Madrid.
Clin Oral Implants Res. 2012 Mar;23(3):316-24. doi: 10.1111/j.1600-0501.2011.02260.x. Epub 2011 Nov 14.
The aim of this controlled randomized clinical trial was to evaluate the efficacy of a xenogeneic collagen matrix (CM) to augment the keratinized tissue around implants supporting prosthetic restorations at 6 months when compared with the standard treatment, the connective tissue autograft, CTG).
This randomized longitudinal parallel controlled clinical trial studied 24 patients with at least one location with minimal keratinized tissue (≤1 mm).
The 6-month width of keratinized tissue. As secondary outcomes the esthetic outlook, the maintenance of peri-implant mucosal health and the patient morbidity were assessed pre-operatively and 1, 3, and 6 months post-operatively.
At 6 months, Group CTG attained a mean width of keratinized tissue of 2.75 (1.5) mm, while the corresponding figure in Group CM was 2.8 (0.4) mm, the inter-group differences not being statistically significant. The surgical procedure in both groups did not alter significantly the mucosal health in the affected abutments. There was a similar esthetic result and significant increase in the vestibular depth in both groups as a result of the surgery. In the CM group it changed from 2.2 (3.3) to 5.1 (2.5) mm at 6 months. The patients treated with the CM referred less pain, needed less pain medication, and the surgical time was shorter, although these differences were not statistically significant when compared with the CTG group.
These results prove that this new CM was as effective and predictable as the CTG for attaining a band of keratinized tissue.
本对照随机临床试验旨在评估异种胶原基质（CM）在增强种植体周围角化组织方面的疗效，与标准治疗方法（结缔组织自体移植物，CTG）相比，在 6 个月时使用 CM 处理可增加角化组织，这一结果优于 CTG。
本随机纵向平行对照临床试验共纳入 24 名患者，这些患者至少有一个部位角化组织量少（≤1mm）。
角化组织的 6 个月宽度。作为次要结局，评估术前和术后 1、3、6 个月的美学外观、种植体周围黏膜健康的维持情况和患者的发病率。
在 6 个月时，CTG 组的角化组织平均宽度为 2.75（1.5）mm，CM 组的相应值为 2.8（0.4）mm，两组间差异无统计学意义。两组的手术程序均未显著改变受影响基台的黏膜健康。手术均能使两组的美学效果相似，且前庭深度显著增加。CM 组从 2.2（3.3）mm 增加到 6 个月时的 5.1（2.5）mm。与 CTG 组相比，CM 组的患者疼痛程度较轻，需要的止痛药物较少，手术时间较短，但这些差异无统计学意义。
这些结果证明，这种新型 CM 与 CTG 一样有效且可预测，能够获得角化组织带。
