Department of Dermatology, Institute of Battle Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.
Photodermatol Photoimmunol Photomed. 2011 Dec;27(6):297-303. doi: 10.1111/j.1600-0781.2011.00616.x.
To analyze the prevalence and significance of FOXP3+ infiltration into (pre)malignant skin carcinomas following ultraviolet radiation (UVR) exposure. The possible pathways that UVR impacts on FOXP3 are to be discussed.
FOXP3+ regulatory T cells (FOXP3+ Tregs) are correlated to cutaneous squamous tumor progression. However, there is no information describing the prevalence of FOXP3+ infiltration in cutaneous premalignant and malignant squamous carcinomas with UVR exposure.
We investigated the prevalence of FOXP3+ infiltration in 14 patients with Bowen's disease, 40 squamous cell carcinoma SCC patients and 21 patients with basal cell carcinoma (BCC) by immunohistochemistry.
The percentages of FOXP3+ vs. total peri-neoplasm infiltration cells (FOXP3+ PCT) were significantly higher in Bowen's disease and well-differentiated SCC that were exposed to UVR than these diseases not exposed to UVR (t = 3.5776, P = 0.0038; t' = 5.9214, P < 0.01, respectively). FOXP3+ PCT was also higher in less pigmented than pigmented sites in BCC (t = 3.369, P = 0.0032).
This study shed some light on the effect of UVR on FOXP3+ infiltration in skin (pre)malignant carcinomas. Our data suggested that FOXP3+ infiltration was positively related to UVR exposure. The mechanisms merit further investigation.
分析紫外线（UVR）辐射暴露后（前）恶性皮肤癌中 FOXP3+浸润的流行率和意义。要讨论 UVR 影响 FOXP3 的可能途径。
FOXP3+调节性 T 细胞（FOXP3+Tregs）与皮肤鳞状肿瘤进展相关。然而，尚无描述 UVR 暴露下皮肤前恶性鳞状细胞癌中 FOXP3+浸润流行率的信息。
我们通过免疫组织化学法研究了 14 例 Bowen 病患者、40 例鳞状细胞癌（SCC）患者和 21 例基底细胞癌（BCC）患者中 FOXP3+浸润的流行率。
与未暴露于 UVR 的 Bowen 病和分化良好的 SCC 相比，暴露于 UVR 的 Bowen 病和分化良好的 SCC 中 FOXP3+与肿瘤周围浸润细胞（FOXP3+PCT）的百分比显著更高（t=3.5776，P=0.0038；t'=5.9214，P<0.01）。BCC 中色素沉着较少的部位 FOXP3+PCT 也高于色素沉着较多的部位（t=3.369，P=0.0032）。
本研究阐明了 UVR 对皮肤（前）恶性癌中 FOXP3+浸润的影响。我们的数据表明，FOXP3+浸润与 UVR 暴露呈正相关。值得进一步研究其机制。
