硫酸软骨素“摆动基序”调节神经干细胞及其后代的维持和分化。
Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny.
机构信息
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
出版信息
J Biol Chem. 2012 Jan 27;287(5):2935-42. doi: 10.1074/jbc.R111.298430. Epub 2011 Nov 17.
Abstract
Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the central nervous system, have the potential to interact with a wide range of growth factors and neurotrophic factors that influence neuronal migration, axon guidance pathways, and neurite outgrowth. Recent studies have also revealed the role of CS/DS chains in the orchestration of the neural stem/progenitor cell micromilieu. Individual functional proteins recognize a set of multiple overlapping oligosaccharide sequences decorated to give different sulfation patterns, which are termed here "wobble CS/DS oligosaccharide motifs," and induce signaling pathways essential for the proliferation, self-renewal, and cell lineage commitment of neural stem/progenitor cells.
摘要
软骨素硫酸盐/硫酸皮肤素（CS/DS）蛋白聚糖是中枢神经系统的主要成分，它们有可能与多种生长因子和神经营养因子相互作用，这些因子影响神经元迁移、轴突导向途径和神经突生长。最近的研究还揭示了 CS/DS 链在神经干细胞/祖细胞微环境协调中的作用。单个功能蛋白识别一组多个重叠的寡糖序列，这些序列被修饰以产生不同的硫酸化模式，这里称为“摆动 CS/DS 寡糖基序”，并诱导对神经干细胞/祖细胞的增殖、自我更新和细胞谱系决定至关重要的信号通路。
相似文献
1
Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny.硫酸软骨素“摆动基序”调节神经干细胞及其后代的维持和分化。
J Biol Chem. 2012 Jan 27;287(5):2935-42. doi: 10.1074/jbc.R111.298430. Epub 2011 Nov 17.
2
Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance.多种硫酸软骨素/硫酸皮肤素硫酸转移酶在胚胎和成年中枢神经系统神经源性区域的表达表明，复杂的硫酸软骨素在神经干细胞维持中发挥作用。
Stem Cells. 2008 Mar;26(3):798-809. doi: 10.1634/stemcells.2007-0448. Epub 2007 Dec 13.
3
Recent advances in the structural study of functional chondroitin sulfate and dermatan sulfate in health and disease.健康与疾病中功能性硫酸软骨素和硫酸皮肤素结构研究的最新进展。
Connect Tissue Res. 2008;49(3):133-9. doi: 10.1080/03008200802148546.
4
Differential gene expression of multiple chondroitin sulfate modification enzymes among neural stem cells, neurons and astrocytes.多种软骨素硫酸修饰酶在神经干细胞、神经元和星形胶质细胞中的差异表达。
Neurosci Lett. 2011 Apr 15;493(3):107-11. doi: 10.1016/j.neulet.2011.02.019. Epub 2011 Feb 12.
5
Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines.不同生物来源的硫酸软骨素和硫酸皮肤素与肝素结合生长因子和细胞因子的相互作用。
Glycoconj J. 2013 Aug;30(6):619-32. doi: 10.1007/s10719-012-9463-5. Epub 2012 Dec 29.
6
Analysis of the structure and neuritogenic activity of chondroitin sulfate/dermatan sulfate hybrid chains from porcine fetal membranes.分析猪胎膜中硫酸软骨素/硫酸皮肤素杂合链的结构和神经突生成活性。
Glycoconj J. 2010 Jan;27(1):49-60. doi: 10.1007/s10719-009-9253-x. Epub 2009 Aug 29.
7
Glycosaminoglycans and chondroitin/dermatan sulfate proteoglycans in the myocardium of a non-human primate.非人类灵长类动物心肌中的糖胺聚糖和硫酸软骨素/硫酸皮肤素蛋白聚糖
Matrix. 1993 Sep;13(5):363-71. doi: 10.1016/s0934-8832(11)80041-7.
8
Studies on the chemistry of arterial wall, XVII. Metabolic characteristics of different types of chondroitin sulfate-dermatan sulfate hybrids in arterial tissue.动脉壁化学研究，第十七部分：动脉组织中不同类型硫酸软骨素-硫酸皮肤素杂合物的代谢特征
Hoppe Seylers Z Physiol Chem. 1975 Oct;356(10):1517-25. doi: 10.1515/bchm2.1975.356.2.1517.
9
Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44.一种大型硫酸软骨素/硫酸皮肤素蛋白聚糖（多功能蛋白聚糖）与L-选择素、P-选择素和CD44的结合。
J Biol Chem. 2000 Nov 10;275(45):35448-56. doi: 10.1074/jbc.M003387200.
10
Dermatan sulphate promotes neuronal differentiation in mouse and human stem cells.硫酸皮肤素促进鼠源和人源干细胞的神经元分化。
J Biochem. 2021 Feb 6;169(1):55-64. doi: 10.1093/jb/mvaa087.
引用本文的文献
1
The Uremic Toxins Inorganic Phosphate, Indoxylsulphate, p-Cresylsulphate, and TMAO Induce the Generation of Sulphated Glycosaminoglycans in Aortic Tissue and Vascular Cells via pAKT Signaling: A Missing Link in the "Gut-Matrix Axis".尿毒症毒素无机磷酸盐、吲哚硫酸盐、对甲酚硫酸盐和氧化三甲胺通过pAKT信号通路诱导主动脉组织和血管细胞中硫酸化糖胺聚糖的生成：“肠-基质轴”中缺失的环节
Toxins (Basel). 2025 Apr 25;17(5):217. doi: 10.3390/toxins17050217.
2
Biomimetic strategies for the deputization of proteoglycan functions.用于替代蛋白聚糖功能的仿生策略。
Front Cell Dev Biol. 2024 Aug 6;12:1391769. doi: 10.3389/fcell.2024.1391769. eCollection 2024.
3
Neuritogenic glycosaminoglycan hydrogels promote functional recovery after severe traumatic brain injury.神经发生性糖胺聚糖水凝胶促进严重外伤性脑损伤后的功能恢复。
J Neural Eng. 2024 Jun 27;21(3):036058. doi: 10.1088/1741-2552/ad5108.
4
Perineuronal Nets in the CNS: Architects of Memory and Potential Therapeutic Target in Neuropsychiatric Disorders.中枢神经系统中的神经周细胞网络：记忆的建筑师及神经精神疾病的潜在治疗靶点。
Int J Mol Sci. 2024 Mar 18;25(6):3412. doi: 10.3390/ijms25063412.
5
A Review of Chondroitin Sulfate's Preparation, Properties, Functions, and Applications.硫酸软骨素的制备、性质、功能及应用综述。
Molecules. 2023 Oct 15;28(20):7093. doi: 10.3390/molecules28207093.
6
AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells.AKT抑制剂Hu7691诱导神经母细胞瘤细胞分化。
Acta Pharm Sin B. 2023 Apr;13(4):1522-1536. doi: 10.1016/j.apsb.2023.01.024. Epub 2023 Feb 4.
7
Odorant Receptor OR2C1 Is an Essential Modulator of Boar Sperm Capacitation by Binding with Heparin.气味受体 OR2C1 通过与肝素结合对猪精子获能起必需的调节作用。
Int J Mol Sci. 2023 Jan 14;24(2):1664. doi: 10.3390/ijms24021664.
8
Glycosaminoglycan scaffolding and neural progenitor cell transplantation promotes regenerative immunomodulation in the mouse ischemic brain.糖胺聚糖支架和神经祖细胞移植促进了小鼠缺血性脑内的再生免疫调节。
Exp Neurol. 2022 Nov;357:114177. doi: 10.1016/j.expneurol.2022.114177. Epub 2022 Jul 20.
9
Editorial: Roles of Chondroitin Sulfate and Dermatan Sulfate as Regulators for Cell and Tissue Development.社论：硫酸软骨素和硫酸皮肤素作为细胞和组织发育调节因子的作用
Front Cell Dev Biol. 2022 Jun 8;10:941178. doi: 10.3389/fcell.2022.941178. eCollection 2022.
10
Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats.大鼠脐带血来源的干细胞中硫酸软骨素的特性。
PLoS One. 2022 Jan 25;17(1):e0262854. doi: 10.1371/journal.pone.0262854. eCollection 2022.
本文引用的文献
1
Adult neurogenesis in the mammalian brain: significant answers and significant questions.哺乳动物大脑中的成人神经发生：重要的答案和重要的问题。
Neuron. 2011 May 26;70(4):687-702. doi: 10.1016/j.neuron.2011.05.001.
2
Structurally distinct LewisX glycans distinguish subpopulations of neural stem/progenitor cells.结构不同的 LewisX 糖可区分神经干细胞/祖细胞亚群。
J Biol Chem. 2011 May 6;286(18):16321-31. doi: 10.1074/jbc.M110.201095. Epub 2011 Mar 8.
3
Differential gene expression of multiple chondroitin sulfate modification enzymes among neural stem cells, neurons and astrocytes.多种软骨素硫酸修饰酶在神经干细胞、神经元和星形胶质细胞中的差异表达。
Neurosci Lett. 2011 Apr 15;493(3):107-11. doi: 10.1016/j.neulet.2011.02.019. Epub 2011 Feb 12.
4
Glycosaminoglycans as regulators of stem cell differentiation.糖胺聚糖作为干细胞分化的调节剂。
Biochem Soc Trans. 2011 Jan;39(1):383-7. doi: 10.1042/BST0390383.
5
CSPG is a secreted factor that stimulates neural stem cell survival possibly by enhanced EGFR signaling.CSPG 是一种分泌因子，通过增强 EGFR 信号可能刺激神经干细胞存活。
PLoS One. 2010 Dec 14;5(12):e15341. doi: 10.1371/journal.pone.0015341.
6
Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain.硫酸皮肤素差向异构酶 2 是在出生后发育的小鼠脑中形成硫酸软骨素/硫酸皮肤素杂合结构的主要同工酶。
Glycobiology. 2011 May;21(5):565-74. doi: 10.1093/glycob/cwq208. Epub 2010 Dec 21.
7
The dynamic glycome microenvironment and stem cell differentiation into vasculature.动态糖基微环境与干细胞向脉管系统分化。
Stem Cells Dev. 2011 May;20(5):749-58. doi: 10.1089/scd.2010.0454. Epub 2011 Jan 4.
8
Regulatory mechanisms that mediate tenascin C-dependent inhibition of oligodendrocyte precursor differentiation.介导 tenascin C 依赖性抑制少突胶质前体细胞分化的调节机制。
J Neurosci. 2010 Sep 15;30(37):12310-22. doi: 10.1523/JNEUROSCI.4957-09.2010.
9
Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies.肝素硫酸在哺乳动物大脑发育中的作用：基于 Ext1 条件性敲除研究的新观点。
Prog Mol Biol Transl Sci. 2010;93:133-52. doi: 10.1016/S1877-1173(10)93007-X.
10
Opposing functions of chondroitin sulfate and heparan sulfate during early neuronal polarization.硫酸软骨素和硫酸乙酰肝素在早期神经元极化过程中的拮抗作用。
Neuroscience. 2010 Sep 15;169(4):1535-47. doi: 10.1016/j.neuroscience.2010.06.027. Epub 2010 Jun 19.
Zotero 插件