Kaplan Jeffrey B
Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA.
Int J Artif Organs. 2011 Sep;34(9):737-51. doi: 10.5301/ijao.5000027.
Surface-attached colonies of bacteria known as biofilms play a major role in the pathogenesis of device-related infections. Biofilm colonies are notorious for their resistance to suprainhibitory concentrations of antibiotics. Numerous studies have shown that subminimal inhibitory concentrations of some antibiotics can act as agonists of bacterial biofilm formation in vitro, a process that may have clinical relevance. This article reviews studies demonstrating that low-dose antibiotics induce bacterial biofilm formation. These studies have provided important information about the regulation of biofilm formation and the signaling pathways involved in global gene regulation in response to cell stressors. It is still unclear whether antibiotic-induced biofilm formation contributes to the inconsistent success of antimicrobial therapy for device infections.
被称为生物膜的细菌表面附着菌落，在与装置相关感染的发病机制中起主要作用。生物膜菌落在抵抗超抑制浓度抗生素方面声名狼藉。大量研究表明，某些抗生素的亚最小抑菌浓度在体外可作为细菌生物膜形成的激动剂，这一过程可能具有临床相关性。本文综述了表明低剂量抗生素诱导细菌生物膜形成的研究。这些研究提供了有关生物膜形成调控以及细胞应激反应中涉及全局基因调控的信号通路的重要信息。抗生素诱导的生物膜形成是否导致装置感染抗菌治疗效果不一致仍不清楚。
