Visai Livia, De Nardo Luigi, Punta Carlo, Melone Lucio, Cigada Alberto, Imbriani Marcello, Arciola Carla Renata
Department of Molecular Medicine and Center for Tissue Engineering (CIT), University of Pavia, Pavia, Italy.
Int J Artif Organs. 2011 Sep;34(9):929-46. doi: 10.5301/ijao.5000050.
Titanium oxide is a heterogeneous catalyst whose efficient photoinduced activity, related to some of its allotropic forms, paved the way for its widespread technological use. Here, we offer a comparative analysis of the use of titanium oxide as coating for materials in biomedical devices. First, we introduce the photoinduced catalytic mechanisms of TiO2 and their action on biological environment and bacteria. Second, we overview the main physical and chemical technologies for structuring suitable TiO2 coatings on biomedical devices. We then present the approaches for in vitro characterization of these surfaces. Finally, we discuss the main aspects of TiO2 photoactivated antimicrobial activity on medical devices and limitations for these types of applications.
氧化钛是一种多相催化剂，其与某些同素异形体相关的高效光诱导活性为其广泛的技术应用铺平了道路。在此，我们对氧化钛作为生物医学设备材料涂层的应用进行了比较分析。首先，我们介绍了TiO₂的光诱导催化机制及其对生物环境和细菌的作用。其次，我们概述了在生物医学设备上构建合适的TiO₂涂层的主要物理和化学技术。然后，我们介绍了这些表面的体外表征方法。最后，我们讨论了TiO₂光活化抗菌活性在医疗设备上的主要方面以及这类应用的局限性。
