Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
J Surg Oncol. 2012 Sep 1;106(3):327-31. doi: 10.1002/jso.22141. Epub 2011 Nov 17.
UbcH10 is an important regulator for the mitotic spindle assembly checkpoint pathway that regulates cell-cycle progression. Overexpression of UbcH10 significantly correlated with advanced tumor grade and high cell proliferation.
The expression of UbcH10 and Ki-67 in meningioma tissues were evaluated immunohistochemically in 47 patients with meningiomas. The correlation of UbcH10 immunoreactivity with clinicopathological features and the prognostic value of UbcH10 in patients were also analyzed.
Immunohistochemistry showed an increase in UbcH10 labeling index in atypical and anaplastic meningiomas versus classical meningiomas (10.53 ± 5.79% vs. 4.23 ± 2.85%, P < 0.001). There was a positive correlation between UbcH10 and Ki-67 immunoreactivity (Spearman r = 0.77, P < 0.001). Clinicopathological evaluation suggested that UbcH10 expression was associated with tumor grade and recurrence (P < 0.05). Kaplan-Meier survival analysis and Cox multivariate analysis revealed a significant correlation between high levels of UbcH10 immunoreactivity and high rates of tumor recurrence.
We conclude that UbcH10 may play important roles in the development of meningioma, high UbcH10 labeling index indicates higher grade of meningioma, and UbcH10 may be a useful molecular marker for predicting the prognosis of meningioma.
UbcH10 是调控有丝分裂纺锤体组装检验点途径的重要调控因子，该途径调控细胞周期进程。UbcH10 的过表达与肿瘤高级别和高细胞增殖显著相关。
在 47 例脑膜瘤患者中，通过免疫组织化学评估脑膜瘤组织中 UbcH10 和 Ki-67 的表达。还分析了 UbcH10 免疫反应性与临床病理特征的相关性以及 UbcH10 对患者的预后价值。
免疫组织化学显示，非典型和间变性脑膜瘤中 UbcH10 标记指数较经典脑膜瘤增加（10.53±5.79%比 4.23±2.85%，P<0.001）。UbcH10 和 Ki-67 免疫反应性之间存在正相关（Spearman r=0.77，P<0.001）。临床病理评估表明，UbcH10 表达与肿瘤分级和复发相关（P<0.05）。Kaplan-Meier 生存分析和 Cox 多变量分析显示，UbcH10 高免疫反应性与肿瘤高复发率之间存在显著相关性。
我们得出结论，UbcH10 可能在脑膜瘤的发生发展中发挥重要作用，UbcH10 高标记指数表明脑膜瘤级别较高，UbcH10 可能是预测脑膜瘤预后的有用分子标志物。
