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用于治疗注意力缺陷多动障碍的处方兴奋剂药物的滥用及相关物质使用模式:大学生中的初步分析

Misuse of prescribed stimulant medication for ADHD and associated patterns of substance use: preliminary analysis among college students.

作者信息

Sepúlveda Dalissa R, Thomas Lisl M, McCabe Sean Esteban, Cranford James A, Boyd Carol J, Teter Christian J

机构信息

School of Pharmacy, Northeastern University, Boston, MA, USA.

出版信息

J Pharm Pract. 2011 Dec;24(6):551-60. doi: 10.1177/0897190011426558. Epub 2011 Nov 17.

Abstract

OBJECTIVES

To explore the prevalence and characteristics associated with college students who misuse their prescribed stimulants for attention-deficit hyperactivity disorder (ADHD) and examine diversion and substance use behaviors as a function of misuse.

METHODS

Cohort of 55 past-year prescribed stimulant users was identified from a random sample (n = 1738) at a large Midwestern research university following the self-administration of a web-based survey. An index was created to assess misuse of prescribed stimulants (i.e., Misuse Index).

RESULTS

Of 55 college students who reported past-year use of prescribed stimulants for ADHD, 22 (40%) endorsed at least one item on the misuse index. The most frequently endorsed misuse items were used too much (36%), self-reported misuse (19%), and intentionally used with alcohol or other drugs (19%). Misusers of prescribed stimulant medication were more likely to report cigarette smoking (p = 0.022), binge drinking (p = 0.022), illicit use of cocaine (p = 0.032), and screen positive on the Drug Abuse Screening test (DAST-10) criteria (p = 0.002). The bivariate odds ratio for the DAST-10 findings was 8.4 (95% CI: 2.0-34.6). Diversion of prescribed stimulants was common (36%) and occurred more frequently among stimulant misusers (57%; p = 0.008).

CONCLUSION

There is a strong relationship between misuse of prescribed stimulants for ADHD and substance use behaviors, as well as other deleterious behaviors such as diversion. These findings suggest the need for close screening, assessment, and therapeutic monitoring of medication use in the college population.

摘要

目的

探讨滥用用于治疗注意力缺陷多动障碍(ADHD)的处方兴奋剂的大学生的患病率及相关特征,并研究作为滥用函数的药物转移和物质使用行为。

方法

在中西部一所大型研究型大学的随机样本(n = 1738)中,通过基于网络的调查自我管理,确定了55名过去一年使用过处方兴奋剂的人群。创建了一个指数来评估处方兴奋剂的滥用情况(即滥用指数)。

结果

在55名报告过去一年使用处方兴奋剂治疗ADHD的大学生中,22人(40%)认可滥用指数上的至少一项。最常被认可的滥用项目是用药过量(36%)、自我报告的滥用(19%)以及故意与酒精或其他药物一起使用(19%)。处方兴奋剂滥用者更有可能报告吸烟(p = 0.022)、狂饮(p = 0.022)、非法使用可卡因(p = 0.032),并且在药物滥用筛查测试(DAST - 10)标准下筛查呈阳性(p = 0.002)。DAST - 10结果的双变量优势比为8.4(95%置信区间:2.0 - 34.6)。处方兴奋剂的药物转移很常见(36%),并且在兴奋剂滥用者中更频繁发生(57%;p = 0.008)。

结论

ADHD处方兴奋剂的滥用与物质使用行为以及其他有害行为(如药物转移)之间存在密切关系。这些发现表明需要对大学生群体的药物使用进行密切筛查、评估和治疗监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2504/3277944/a024216f9784/nihms352017f1.jpg

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