Department of Physics, University of Wisconsin, Madison, Wisconsin, USA.
J Magn Reson Imaging. 2012 Mar;35(3):518-27. doi: 10.1002/jmri.23501. Epub 2011 Nov 16.
To develop a method for targeted volumetric, three directional cine phase contrast (PC) imaging with high spatial resolution in clinically feasible scan times.
A hybrid radial-Cartesian k-space trajectory is used for cardiac gated, volumetric imaging with three directional velocity encoding. Imaging times are reduced by radial undersampling and temporal viewsharing. Phase contrast angiograms are displayed in a new approach that addresses the concern of signal drop out in regions of slow flow. The feasibility of the PC stack of stars (SOS) trajectory was demonstrated with an in vivo study capturing 14 small intracranial aneurysms (2-10 mm). Aneurysm measures from six aneurysms also imaged with digital subtraction angiography (DSA) were compared with linear regression with those from the PC SOS images.
All aneurysms were identified on the phase contrast angiograms. The geometric measures from PC SOS and DSA were in good agreement (linear regression: slope = 0.89, intercept = 0.35, R∧2 = 0.88).
PC SOS is a promising method for obtaining volumetric angiograms and cine phase contrast velocity measurements in three dimensions. Acquired spatial resolutions of 0.4 × 0.4 × (0.7-1.0) mm make this method especially promising for studying flow in small intracranial aneurysms.
开发一种方法，用于在临床可行的扫描时间内实现具有高空间分辨率的靶向容积、三维电影相位对比（PC）成像。
采用混合径向-笛卡尔 k 空间轨迹进行心脏门控、容积成像，并具有三维速度编码。通过径向欠采样和时间视图共享来缩短成像时间。相位对比血管造影图采用新方法显示，该方法解决了在缓慢血流区域信号丢失的问题。通过对 14 个小颅内动脉瘤（2-10 毫米）进行活体研究，证明了 PC 星堆（SOS）轨迹的可行性。还将从六个动脉瘤的 PC SOS 图像和数字减影血管造影（DSA）获得的测量值进行线性回归比较。
相位对比血管造影图上均能识别出所有动脉瘤。PC SOS 和 DSA 的几何测量值非常吻合（线性回归：斜率=0.89，截距=0.35，R∧2=0.88）。
PC SOS 是一种很有前途的方法，可用于获得容积血管造影图和三维电影相位对比速度测量值。获得的 0.4×0.4×（0.7-1.0）mm 的空间分辨率使该方法特别适用于研究小颅内动脉瘤中的血流。
