Rogers David, Boyd Douglas D, Fox Erin E, Cooper Sharon, Goldhagen Marc, Shen Yu, Del Junco Deborah J
MD Anderson Cancer Center, Houston, TX 77030, USA.
Aviat Space Environ Med. 2011 Nov;82(11):1067-70. doi: 10.3357/asem.3090.2011.
Several studies investigating whether prostate cancer incidence is elevated in aviators both in the civilian and military sectors have yielded inconsistent findings. Most investigations have compared aviators to the general population. Instead, our study compared prostate cancer incidence rates among officer aviators and non-aviators in the U.S. Air Force (USAF) to reduce confounding by socioeconomic status and frequency of medical exams.
This retrospective analysis ascertained prostate cancer cases using the Automated Cancer Tumor Registry of the Department of Defense linked to personnel records from the USAF Personnel Center to identify aviators and non-aviators. Survival analysis using the Cox Proportional Hazards model allowed comparison of prostate cancer incidence rates in USAF aviators and non-aviators.
After adjustment for age and race, the hazards ratio for prostate cancer incidence comparing aviators with non-aviators was 1.15 (95% confidence interval, 0.85-1.44). Neither prostate cancer incidence nor time to diagnosis differed significantly between the two groups.
Our study compared prostate cancer rates in aviators with a reference group of non-aviators similar in socio-economic level and frequency of exams. When compared to this internal reference group the risk of prostate cancer in USAF officer aviators appeared similar with no significant excess.
多项针对民航和军事领域飞行员前列腺癌发病率是否升高的研究结果并不一致。大多数调查将飞行员与普通人群进行了比较。相反，我们的研究比较了美国空军（USAF）军官飞行员和非飞行员的前列腺癌发病率，以减少社会经济地位和体检频率带来的混杂因素影响。
这项回顾性分析通过国防部的自动癌症肿瘤登记系统确定前列腺癌病例，并将其与美国空军人员中心的人事记录相链接，以识别飞行员和非飞行员。使用Cox比例风险模型进行生存分析，以便比较美国空军飞行员和非飞行员的前列腺癌发病率。
在对年龄和种族进行调整后，飞行员与非飞行员相比，前列腺癌发病率的风险比为1.15（95%置信区间，0.85 - 1.44）。两组之间的前列腺癌发病率和诊断时间均无显著差异。
我们的研究将飞行员的前列腺癌发病率与社会经济水平和体检频率相似的非飞行员参照组进行了比较。与这个内部参照组相比，美国空军军官飞行员患前列腺癌的风险似乎相似，没有显著增加。
