Rose M E, Wakelin D, Hesketh P
Houghton Laboratory, Institute for Animal Health, Huntingdon, Cambridgeshire, England, U.K.
Exp Parasitol. 1990 Oct;71(3):276-83. doi: 10.1016/0014-4894(90)90032-8.
BALB/c and C57BL/6 mice are high- and low-responders, respectively, to infection with Eimeria vermiformis, this genetically determined difference being immunologically mediated. In order to identify the level at which response phenotype is determined, the proliferation of mesenteric lymph node cells and their ability to transfer immunity adoptively were investigated in each strain; the development of circulating serum antibodies to E. vermiformis was also determined. In all respects BALB/c mice responded earlier than the C57BL/6 but peak values were similar in both strains. The relationship between the temporal differences noted and the characteristic, differing course of the primary infection in the two strains is discussed.
BALB/c小鼠和C57BL/6小鼠分别是对蠕虫艾美耳球虫感染的高反应者和低反应者，这种遗传决定的差异是由免疫介导的。为了确定决定反应表型的水平，研究了每个品系中肠系膜淋巴结细胞的增殖及其过继转移免疫的能力；还测定了针对蠕虫艾美耳球虫的循环血清抗体的产生情况。在所有方面，BALB/c小鼠的反应都比C57BL/6小鼠早，但两个品系的峰值相似。讨论了所观察到的时间差异与两个品系原发性感染的特征性不同病程之间的关系。
