Paris Est-Creteil University & Henri-Mondor University Hospital (APHP): Reference Center for Neuromuscular Diseases Garches-Necker-Mondor-Hendaye, Creteil, F-94010, France.
J Inorg Biochem. 2011 Nov;105(11):1457-63. doi: 10.1016/j.jinorgbio.2011.08.006. Epub 2011 Aug 22.
Macrophagic myofasciitis (MMF) is characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and cognitive dysfunction. Representative features of MMF-associated cognitive dysfunction (MACD) include (i) dysexecutive syndrome; (i) visual memory; (iii) left ear extinction at dichotic listening test. In present study we retrospectively evaluated the progression of MACD in 30 MMF patients. Most patients fulfilled criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits seemed unusually severe. MACD remained stable over time, although dysexecutive syndrome tended to worsen. Long-term follow-up of a subset of patients with 3 or 4 consecutive neuropsychological evaluations confirmed the stability of MACD with time, despite marked fluctuations.
巨噬细胞肌炎（MMF）的特征是在先前免疫部位的巨噬细胞内存在氢氧化铝的特定肌肉病变，长期持续存在。受影响的患者为中年成年人，主要表现为弥漫性肌痛、慢性疲劳和认知功能障碍。MMF 相关认知功能障碍（MACD）的代表性特征包括：（i）执行功能障碍；（i）视觉记忆；（iii）双听测试中的左耳消失。在本研究中，我们回顾性评估了 30 名 MMF 患者的 MACD 进展情况。大多数患者符合非遗忘/执行功能障碍轻度认知障碍的标准，尽管一些认知缺陷似乎异常严重。MACD 随时间保持稳定，尽管执行功能障碍有恶化趋势。对一组患者进行了 3 或 4 次连续神经心理学评估的长期随访证实了 MACD 随时间的稳定性，尽管存在明显波动。
