Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
Cell Metab. 2011 Dec 7;14(6):718-9. doi: 10.1016/j.cmet.2011.10.006. Epub 2011 Nov 17.
Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylases and are important modulators of energy metabolism and stress resistance. Two new studies by Du et al. (2011) and Peng et al. (2011) identify a new enzymatic activity for SIRT5, expanding the cellular repertoire of posttranslational modifications targeted by the sirtuins.
七种哺乳动物的沉默调节蛋白是烟酰胺腺嘌呤二核苷酸（NAD）（+）依赖性脱乙酰酶，是能量代谢和应激抵抗的重要调节剂。Du 等人（2011 年）和 Peng 等人（2011 年）的两项新研究确定了 SIRT5 的一种新的酶活性，扩大了沉默调节蛋白靶向的细胞内翻译后修饰谱。
