TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy.
作者信息
Peña-Llopis Samuel, Brugarolas James
出版信息
Cell Cycle. 2011 Dec 1;10(23):3987-8. doi: 10.4161/cc.10.23.18251.
Abstract
摘要
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本文引用的文献
1
Transcriptional activation of lysosomal exocytosis promotes cellular clearance.转录激活溶酶体胞吐作用促进细胞清除。
Dev Cell. 2011 Sep 13;21(3):421-30. doi: 10.1016/j.devcel.2011.07.016. Epub 2011 Sep 1.
2
Regulation of TFEB and V-ATPases by mTORC1.mTORC1 对 TFEB 和 V-ATPases 的调节。
EMBO J. 2011 Jul 29;30(16):3242-58. doi: 10.1038/emboj.2011.257.
3
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.对 CLEAR 网络的特征分析揭示了细胞清除途径的综合调控。
Hum Mol Genet. 2011 Oct 1;20(19):3852-66. doi: 10.1093/hmg/ddr306. Epub 2011 Jul 13.
4
mTOR: from growth signal integration to cancer, diabetes and ageing.mTOR：从生长信号整合到癌症、糖尿病和衰老。
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35. doi: 10.1038/nrm3025. Epub 2010 Dec 15.
5
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.mTOR 复合物 1 下游代谢基因调控网络的激活。
Mol Cell. 2010 Jul 30;39(2):171-83. doi: 10.1016/j.molcel.2010.06.022.
6
Termination of autophagy and reformation of lysosomes regulated by mTOR.mTOR 调控的自噬终止和溶酶体的再形成。
Nature. 2010 Jun 17;465(7300):942-6. doi: 10.1038/nature09076. Epub 2010 Jun 6.
7
A gene network regulating lysosomal biogenesis and function.一个调节溶酶体生物发生和功能的基因网络。
Science. 2009 Jul 24;325(5939):473-7. doi: 10.1126/science.1174447. Epub 2009 Jun 25.
8
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.固醇调节元件结合蛋白（SREBP）的活性受哺乳动物雷帕霉素靶蛋白复合物1（mTORC1）调控，并促进Akt依赖的细胞生长。
Cell Metab. 2008 Sep;8(3):224-36. doi: 10.1016/j.cmet.2008.07.007.
9
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.mTOR抑制通过调节凋亡和HIF-1依赖途径逆转Akt依赖的前列腺上皮内瘤变。
Nat Med. 2004 Jun;10(6):594-601. doi: 10.1038/nm1052. Epub 2004 May 23.
10
TSC2 regulates VEGF through mTOR-dependent and -independent pathways.结节性硬化症复合物2（TSC2）通过mTOR依赖和非依赖途径调节血管内皮生长因子（VEGF）。
Cancer Cell. 2003 Aug;4(2):147-58. doi: 10.1016/s1535-6108(03)00187-9.
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