伊朗外周动脉疾病患者中严重颈动脉狭窄的患病率。

Prevalence of significant carotid artery stenosis in Iranian patients with peripheral arterial disease.

作者信息

Bavil Abolhassan Shakeri, Ghabili Kamyar, Daneshmand Seyed Ebrahim, Nemati Masoud, Bavil Moslem Shakeri, Namdar Hossein, Shaafi Sheyda

机构信息

Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Vasc Health Risk Manag. 2011;7:629-32. doi: 10.2147/VHRM.S23979. Epub 2011 Oct 11.

DOI:10.2147/VHRM.S23979

PMID:22102786

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3212428/

Abstract

BACKGROUND

Generalized screening for carotid artery stenosis with carotid duplex ultrasonography in patients with peripheral arterial disease is controversial.

OBJECTIVES

The aim of the present study was to determine the prevalence of significant internal carotid artery (ICA) stenosis in a group of Iranian patients with peripheral arterial disease.

METHODS

We prospectively screened 120 patients with a known diagnosis of peripheral vascular disease for carotid artery stenosis. Based on the angiographic assessment of abdominal aorta and arteries of the lower extremities, patients with stenosis greater than 70% in the lower extremity arteries were included. A group of healthy individuals aged ≥ 50 years was recruited as a control. Risk factors for atherosclerosis including smoking, diabetes mellitus, hyperlipidemia, ischemic heart disease, and cerebrovascular disease were recorded. Common carotid arteries (CCAs) and the origins of the internal and external arteries were scanned with B-mode ultrasonography. Significant ICA stenosis, > 70% ICA stenosis but less than near occlusion of the ICA, was diagnosed when the ICA/CCA peak systolic velocity ratio was ≥ 3.5.

RESULTS

Ninety-five patients, with a mean age of 58.52 ± 11.04 years, were studied. Twenty-five patients had a history of smoking, six patients had a history of coronary artery disease, six patients had hypertension, and ten patients had diabetes mellitus. Significant ICA stenosis was present in four patients (4.2%) with peripheral arterial disease in one healthy individual (1%) of the control group (P > 0.05). In terms of the risk factors for atherosclerosis, no statistically significant relationship was found between individual atherosclerotic risk factors and significant ICA stenosis (P > 0.05).

CONCLUSION

The prevalence of significant ICA stenosis in Iranian patients with peripheral arterial disease is low. In addition, there is no relationship between individual atherosclerotic risk factors and significant ICA stenosis.

摘要

背景

对外周动脉疾病患者进行颈动脉双功超声检查以筛查颈动脉狭窄存在争议。

目的

本研究旨在确定一组伊朗外周动脉疾病患者中重度颈内动脉（ICA）狭窄的患病率。

方法

我们前瞻性地筛查了120例已知诊断为外周血管疾病的患者是否存在颈动脉狭窄。根据腹主动脉和下肢动脉的血管造影评估，纳入下肢动脉狭窄大于70%的患者。招募一组年龄≥50岁的健康个体作为对照。记录动脉粥样硬化的危险因素，包括吸烟、糖尿病、高脂血症、缺血性心脏病和脑血管疾病。用B型超声扫描颈总动脉（CCA）以及颈内和颈外动脉的起始部。当ICA/CCA收缩期峰值流速比≥3.5时，诊断为重度ICA狭窄，即ICA狭窄>70%但小于ICA近乎闭塞。

结果

对95例平均年龄为58.52±11.04岁的患者进行了研究。25例患者有吸烟史，6例患者有冠状动脉疾病史，6例患者有高血压，10例患者有糖尿病。外周动脉疾病患者中有4例（4.2%）存在重度ICA狭窄，对照组1例健康个体中有1例（1%）存在重度ICA狭窄（P>0.05）。就动脉粥样硬化的危险因素而言，未发现个体动脉粥样硬化危险因素与重度ICA狭窄之间存在统计学显著相关性（P>0.05）。