脑酮代谢在发育和损伤过程中的作用。
Cerebral ketone metabolism during development and injury.
机构信息
Department of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7039, USA.
出版信息
Epilepsy Res. 2012 Jul;100(3):218-23. doi: 10.1016/j.eplepsyres.2011.09.027. Epub 2011 Nov 21.
Abstract
Cerebral metabolism of ketones is a normal part of the process of brain development. While the mature brain relies on glucose as a primary fuel source, metabolism of ketone bodies remains an alternative energy source under conditions of starvation. The neuroprotective properties of brain ketone metabolism make this alternative substrate a viable therapeutic option for various pathologies. Since the ability to revert to utilizing ketones as an alternative substrate is greatest in the younger post-weaned brain, this particular therapeutic approach remains an untapped resource particularly for pediatric pathological conditions.
摘要
酮体在大脑中的代谢是大脑发育过程中的正常部分。虽然成熟的大脑依赖葡萄糖作为主要燃料来源，但在饥饿条件下，酮体的代谢仍然是一种替代能源。大脑酮代谢的神经保护特性使这种替代底物成为各种病理情况下可行的治疗选择。由于在断奶后的年轻大脑中恢复利用酮体作为替代底物的能力最大，因此这种特殊的治疗方法仍然是一种未开发的资源，特别是对于儿科病理情况。
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本文引用的文献
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2
The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma.生酮饮食作为脑胶质瘤的辅助治疗方法可逆转基因表达模式并降低活性氧水平。
Nutr Metab (Lond). 2010 Sep 10;7:74. doi: 10.1186/1743-7075-7-74.
3
Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.给予生酮饮食的幼年和成年大鼠可减轻疼痛和炎症。
PLoS One. 2009 Dec 23;4(12):e8349. doi: 10.1371/journal.pone.0008349.
4
The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats.生酮饮食对幼鼠创伤性脑损伤诱导的细胞死亡的保护作用。
Brain Inj. 2009 May;23(5):459-65. doi: 10.1080/02699050902788469.
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The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat.生酮饮食对幼年和成年大鼠控制性皮质撞击损伤后行为结果的影响。
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