脑酮代谢在发育和损伤过程中的作用。
Cerebral ketone metabolism during development and injury.
机构信息
Department of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7039, USA.
出版信息
Epilepsy Res. 2012 Jul;100(3):218-23. doi: 10.1016/j.eplepsyres.2011.09.027. Epub 2011 Nov 21.
Abstract
Cerebral metabolism of ketones is a normal part of the process of brain development. While the mature brain relies on glucose as a primary fuel source, metabolism of ketone bodies remains an alternative energy source under conditions of starvation. The neuroprotective properties of brain ketone metabolism make this alternative substrate a viable therapeutic option for various pathologies. Since the ability to revert to utilizing ketones as an alternative substrate is greatest in the younger post-weaned brain, this particular therapeutic approach remains an untapped resource particularly for pediatric pathological conditions.
摘要
酮体在大脑中的代谢是大脑发育过程中的正常部分。虽然成熟的大脑依赖葡萄糖作为主要燃料来源，但在饥饿条件下，酮体的代谢仍然是一种替代能源。大脑酮代谢的神经保护特性使这种替代底物成为各种病理情况下可行的治疗选择。由于在断奶后的年轻大脑中恢复利用酮体作为替代底物的能力最大，因此这种特殊的治疗方法仍然是一种未开发的资源，特别是对于儿科病理情况。
相似文献
1
Cerebral ketone metabolism during development and injury.
Epilepsy Res. 2012 Jul;100(3):218-23. doi: 10.1016/j.eplepsyres.2011.09.027. Epub 2011 Nov 21.
2
Cerebral metabolic adaptation and ketone metabolism after brain injury.
J Cereb Blood Flow Metab. 2008 Jan;28(1):1-16. doi: 10.1038/sj.jcbfm.9600543. Epub 2007 Aug 8.
3
Clinical review: ketones and brain injury.
Crit Care. 2011 Apr 6;15(2):219. doi: 10.1186/cc10020.
4
The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury.
J Lipid Res. 2014 Dec;55(12):2450-7. doi: 10.1194/jlr.R046706. Epub 2014 Apr 10.
5
Neuroprotective effects of lactate and ketone bodies in acute brain injury.
J Cereb Blood Flow Metab. 2024 Jul;44(7):1078-1088. doi: 10.1177/0271678X241245486. Epub 2024 Apr 11.
6
Regional ketone body utilization by rat brain in starvation and diabetes.
Am J Physiol. 1986 Feb;250(2 Pt 1):E169-78. doi: 10.1152/ajpendo.1986.250.2.E169.
7
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury.
J Neurosci Res. 2005 Nov 1;82(3):413-20. doi: 10.1002/jnr.20633.
8
The rate of cerebral utilization of glucose, ketone bodies, and oxygen: a comparative in vivo study of infant and adult rats.
Pediatr Res. 1976 Nov;10(11):910-7. doi: 10.1203/00006450-197611000-00002.
9
Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases.
Int J Mol Sci. 2020 Nov 20;21(22):8767. doi: 10.3390/ijms21228767.
10
Modulation of cerebral ketone metabolism following traumatic brain injury in humans.
J Cereb Blood Flow Metab. 2020 Jan;40(1):177-186. doi: 10.1177/0271678X18808947. Epub 2018 Oct 24.
引用本文的文献
1
Ketogenic diet in neonates: effects, pitfalls, and a paradigm from a preterm newborn affected by pyruvate dehydrogenase deficiency.
J Perinatol. 2025 Sep 17. doi: 10.1038/s41372-025-02427-6.
2
Molecular Mechanisms of Neuroprotection by Ketone Bodies and Ketogenic Diet in Cerebral Ischemia and Neurodegenerative Diseases.
Int J Mol Sci. 2023 Dec 21;25(1):124. doi: 10.3390/ijms25010124.
3
Does Ketogenic Diet Used in Pregnancy Affect the Nervous System Development in Offspring?─FTIR Microspectroscopy Study.
ACS Chem Neurosci. 2023 Aug 2;14(15):2775-2791. doi: 10.1021/acschemneuro.3c00331. Epub 2023 Jul 20.
4
Ketogenic diet impairs neurological development of neonatal rats and affects biochemical composition of maternal brains: evidence of functional recovery in pups.
Brain Struct Funct. 2022 Apr;227(3):1099-1113. doi: 10.1007/s00429-021-02450-1. Epub 2022 Jan 17.
5
Ketogenic regimens for acute neurotraumatic events.
Curr Opin Biotechnol. 2021 Aug;70:68-74. doi: 10.1016/j.copbio.2020.12.009. Epub 2021 Jan 11.
6
The Ketogenic Diet in the Treatment of Post-concussion Syndrome-A Feasibility Study.
Front Nutr. 2020 Sep 10;7:160. doi: 10.3389/fnut.2020.00160. eCollection 2020.
7
Simultaneous nicotine and oral contraceptive exposure alters brain energy metabolism and exacerbates ischemic stroke injury in female rats.
J Cereb Blood Flow Metab. 2021 Apr;41(4):793-804. doi: 10.1177/0271678X20925164. Epub 2020 Jun 14.
8
Ketogenic diet in the treatment of cancer - Where do we stand?
Mol Metab. 2020 Mar;33:102-121. doi: 10.1016/j.molmet.2019.06.026. Epub 2019 Jul 27.
9
Sex differences in pediatric traumatic brain injury.
Exp Neurol. 2019 Jul;317:168-179. doi: 10.1016/j.expneurol.2019.02.016. Epub 2019 Mar 2.
10
How to Translate Time: The Temporal Aspects of Rodent and Human Pathobiological Processes in Traumatic Brain Injury.
J Neurotrauma. 2019 Jun;36(11):1724-1737. doi: 10.1089/neu.2018.6261. Epub 2019 Mar 7.
本文引用的文献
1
Metabolic control of vesicular glutamate transport and release.
Neuron. 2010 Oct 6;68(1):99-112. doi: 10.1016/j.neuron.2010.09.002.
2
The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma.
Nutr Metab (Lond). 2010 Sep 10;7:74. doi: 10.1186/1743-7075-7-74.
3
Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.
PLoS One. 2009 Dec 23;4(12):e8349. doi: 10.1371/journal.pone.0008349.
4
The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats.
Brain Inj. 2009 May;23(5):459-65. doi: 10.1080/02699050902788469.
5
The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat.
J Neurotrauma. 2009 Apr;26(4):497-506. doi: 10.1089/neu.2008.0664.
6
Ketones suppress brain glucose consumption.
Adv Exp Med Biol. 2009;645:301-6. doi: 10.1007/978-0-387-85998-9_45.
7
The effects of age and ketogenic diet on local cerebral metabolic rates of glucose after controlled cortical impact injury in rats.
J Neurotrauma. 2009 Jul;26(7):1083-93. doi: 10.1089/neu.2008.0769.
8
Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats.
Ann Clin Lab Sci. 2009 Winter;39(1):76-83.
9
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.
Brain Res Rev. 2009 Mar;59(2):293-315. doi: 10.1016/j.brainresrev.2008.09.002. Epub 2008 Sep 25.
10
Neuroprotection in diet-induced ketotic rat brain after focal ischemia.
J Cereb Blood Flow Metab. 2008 Dec;28(12):1907-16. doi: 10.1038/jcbfm.2008.79. Epub 2008 Jul 23.
Zotero 插件