Grützkau A, Hanski C, Hahn H, Riecken E O
Abteilung für Innere Medizin mit Schwerpunkt Gastroenterologie, Freie Universität Berlin, West Germany.
Gut. 1990 Sep;31(9):1011-5. doi: 10.1136/gut.31.9.1011.
Recent evidence indicates that ileal Peyer's patches represent the main infection route for Yersinia enterocolitica. In this study transmission and scanning electron microscopy have shown that only a small fraction of bacteria present in the lumen adhere to the follicle-associated murine epithelium with no discernible preference for either M or absorptive cells. Yersiniae attached to M cells are phagocytosed and transported from the lumen into the lamina propria. No invasion of columnar absorptive cells was observed. These data, in combination with recently published reports, indicate that the involvement of M cells is a common step in bacterial invasion of Peyer's patches.
最近的证据表明，回肠派尔集合淋巴结是小肠结肠炎耶尔森菌的主要感染途径。在本研究中，透射电子显微镜和扫描电子显微镜显示，肠腔中仅一小部分细菌黏附于滤泡相关的鼠上皮细胞，对M细胞或吸收细胞均无明显偏好。黏附于M细胞的耶尔森菌被吞噬并从肠腔转运至固有层。未观察到柱状吸收细胞被侵袭。这些数据与最近发表的报告相结合，表明M细胞的参与是细菌侵袭派尔集合淋巴结的一个共同步骤。
