红杆菌来源的细胞毒苯并噻唑类化合物 Erythrazoles A-B
Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.
机构信息
Department of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
出版信息
Org Lett. 2011 Dec 16;13(24):6580-3. doi: 10.1021/ol202944g. Epub 2011 Nov 22.
Abstract
Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC(50) values of 1.5, 2.5, and 6.8 μM against H1325, H2122, and HCC366, respectively.
摘要
从红树林沉积物中分离得到的一株红杆菌属(Erythrobacter sp.)的提取物的化学分析得到了 erythrazoles A(1)和 B(2)。这些 erythrazoles 具有混合的生物合成来源，包含一个四取代的苯并噻唑、一个附加的二萜侧链和一个甘氨酸单元。Erythrazole B 对一组非小细胞肺癌(NSCLC)细胞系具有细胞毒性，对 H1325、H2122 和 HCC366 的 IC50 值分别为 1.5、2.5 和 6.8 μM。
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