Centre for International Health, University of Bergen, Bergen, Norway.
J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):785-90. doi: 10.1097/MPG.0b013e318241a683.
Calprotectin is a calcium- and zinc-binding protein and a marker in faeces of gastrointestinal inflammation. Reference values have been established in children older than 4 years. The aim of the present study was to determine the concentration of faecal calprotectin (FC) in human immunodeficiency virus (HIV)-infected, highly active antiretroviral therapy-naïve Ugandan children and compare it with the reference value.
We tested 193 HIV-infected children ages 0 to 12 years in a hospital-based survey for FC. A standardised interview with sociodemographic information and medical history was used to assess risk factors. A cluster of differentiation 4 (CD4) cell percentage was prevalent in all of the children.
The median FC concentrations decreased with increasing age, as in healthy children. The median concentration was 208 mg/kg in infants 0 to 1 year, 171 mg/kg among toddlers 1 to 4 years, and 62 mg/kg for children 4 to 12 years. Children with advanced disease and a low CD4 cell percentage had significantly higher FC concentrations than those with a high CD4 cell percentage. Children older than 4 years with diarrhoea had significantly higher FC concentrations compared with those without diarrhoea.
HIV-infected children older than 4 years had a median FC concentration above the reference value, and gut inflammation in the children with elevated values is likely. Children with more advanced disease had increased FC concentrations regardless of age.
钙卫蛋白是一种钙和锌结合蛋白，是胃肠道炎症粪便中的标志物。参考值已在 4 岁以上儿童中建立。本研究的目的是确定人类免疫缺陷病毒（HIV）感染、未接受高效抗逆转录病毒治疗的乌干达儿童粪便中钙卫蛋白（FC）的浓度，并与参考值进行比较。
我们在一项基于医院的调查中测试了 193 名年龄在 0 至 12 岁的 HIV 感染儿童的 FC。使用标准化的访谈和社会人口统计学信息及病史来评估危险因素。所有儿童均存在 CD4 细胞百分比。
FC 浓度随年龄的增加而降低，与健康儿童相似。0 至 1 岁婴儿的中位 FC 浓度为 208 mg/kg，1 至 4 岁幼儿为 171 mg/kg，4 至 12 岁儿童为 62 mg/kg。晚期疾病和低 CD4 细胞百分比的儿童 FC 浓度显著高于高 CD4 细胞百分比的儿童。4 岁以上有腹泻的儿童 FC 浓度明显高于无腹泻的儿童。
4 岁以上的 HIV 感染儿童的中位 FC 浓度高于参考值，且这些儿童的肠道炎症可能很严重。无论年龄大小，疾病更严重的儿童 FC 浓度均增加。
