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本文引用的文献

1
Antibiotic therapy may improve idiopathic restless legs syndrome: prospective, open-label pilot study of rifaximin, a nonsystemic antibiotic.抗生素治疗可能改善特发性不宁腿综合征：非全身性抗生素利福昔明的前瞻性、开放标签试验研究
Sleep Med. 2010 Apr;11(4):427. doi: 10.1016/j.sleep.2009.06.005. Epub 2009 Dec 29.
2
Celiac disease is associated with restless legs syndrome.乳糜泻与不安腿综合征有关。
Dig Dis Sci. 2010 Jun;55(6):1667-73. doi: 10.1007/s10620-009-0943-9.
3
Crohn's disease is associated with restless legs syndrome.克罗恩病与不安腿综合征有关。
Inflamm Bowel Dis. 2010 Feb;16(2):275-9. doi: 10.1002/ibd.20992.
4
Determinants of quality of life in irritable bowel syndrome.肠易激综合征患者生活质量的决定因素
J Clin Gastroenterol. 2008 Oct;42(9):1003-9. doi: 10.1097/MCG.0b013e31815af9f1.
5
Restless legs syndrome: pathophysiology, diagnosis and treatment.不宁腿综合征：病理生理学、诊断与治疗
CNS Drugs. 2008;22(6):497-518. doi: 10.2165/00023210-200822060-00004.
6
Results of small intestinal bacterial overgrowth testing in irritable bowel syndrome patients: clinical profiles and effects of antibiotic trial.肠易激综合征患者小肠细菌过度生长检测结果：临床特征及抗生素试验的效果
Adv Med Sci. 2007;52:139-42.
7
Restless legs syndrome in patients with irritable bowel syndrome: response to small intestinal bacterial overgrowth therapy.肠易激综合征患者的不安腿综合征：对小肠细菌过度生长治疗的反应。
Dig Dis Sci. 2008 May;53(5):1252-6. doi: 10.1007/s10620-007-0021-0. Epub 2007 Oct 13.
8
Small intestinal bacterial overgrowth in patients with interstitial cystitis and gastrointestinal symptoms.间质性膀胱炎伴胃肠道症状患者的小肠细菌过度生长
Dig Dis Sci. 2008 May;53(5):1246-51. doi: 10.1007/s10620-007-0022-z. Epub 2007 Oct 12.
9
Psychosocial risk markers for new onset irritable bowel syndrome--results of a large prospective population-based study.新发肠易激综合征的心理社会风险标志物——一项基于大规模前瞻性人群研究的结果
Pain. 2008 Jul;137(1):147-155. doi: 10.1016/j.pain.2007.08.029. Epub 2007 Oct 10.
10
Elevated motility-related transmucosal potential difference in the upper small intestine in the irritable bowel syndrome.肠易激综合征患者上小肠中与动力相关的跨黏膜电位差升高。
Neurogastroenterol Motil. 2007 Oct;19(10):812-20. doi: 10.1111/j.1365-2982.2007.00941.x.

肠易激综合征患者不安腿综合征的患病率。

Prevalence of restless legs syndrome in patients with irritable bowel syndrome.

机构信息

Gastroenterology, Hepatology, and Liver Transplant, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States.

出版信息

World J Gastroenterol. 2011 Oct 21;17(39):4404-7. doi: 10.3748/wjg.v17.i39.4404.

DOI:10.3748/wjg.v17.i39.4404
PMID:22110266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3218154/
Abstract

AIM

To determine the prevalence of restless legs syndrome (RLS) in patients with irritable bowel syndrome (IBS).

METHODS

Patients with diarrhea-predominant IBS (n = 30), constipation-predominant IBS (n = 30), or mixed-symptom IBS (n = 30) were recruited from the community between March 2008 and February 2009. Rifaximin 200 mg three times daily was administered empirically to alleviate small intestinal bowel overgrowth in all patients. The presence of RLS was assessed via an RLS questionnaire and polysomnography.

RESULTS

Twenty-six patients with IBS (29%) were diagnosed with RLS using the RLS questionnaire. Twenty-four of the 26 patients (92%) underwent polysomnography, and all had confirmation of RLS. A greater percentage of patients with RLS had diarrhea-predominant IBS (62%) compared with patients with constipation-predominant IBS (4%) or mixed-symptom IBS (33%).

CONCLUSION

Restless legs syndrome is prevalent in patients with IBS, especially those with diarrheal symptoms. Assessment of concomitant disorders may improve diagnosis and expand relevant treatment options for patients.

摘要

目的

确定肠易激综合征（IBS）患者中不宁腿综合征（RLS）的患病率。

方法

2008 年 3 月至 2009 年 2 月期间，从社区招募了腹泻为主型 IBS（n=30）、便秘为主型 IBS（n=30）或混合症状型 IBS（n=30）患者。所有患者均给予利福昔明 200mg，每日 3 次，经验性治疗小肠细菌过度生长。通过 RLS 问卷和多导睡眠图评估 RLS 的存在。

结果

使用 RLS 问卷诊断 26 例 IBS 患者（29%）患有 RLS。26 例患者中的 24 例（92%）接受了多导睡眠图检查，所有患者均证实患有 RLS。与便秘为主型 IBS（4%）或混合症状型 IBS（33%）患者相比，RLS 患者中腹泻为主型 IBS 患者的比例更高（62%）。

结论

RLS 在 IBS 患者中较为普遍，尤其是腹泻症状患者。评估伴随疾病可能会改善诊断，并为患者提供更多相关的治疗选择。