丙型肝炎患者使用α-干扰素和利巴韦林治疗并发浆液性视网膜脱离
Serous Retinal Detachments Complicating Interferon-α and Ribavirin Treatment in Patients with Hepatitis C.
作者信息
Modorati Giulio, Matteo Di Federico, Miserocchi Elisabetta, Colucci Annalisa, Bandello Francesco
机构信息
Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy.
出版信息
Case Rep Ophthalmol. 2011 Jan;2(1):105-10. doi: 10.1159/000326747. Epub 2011 Mar 12.
PURPOSE
To report the cases of two patients with chronic hepatitis C infection showing serous retinal detachments similar to Vogt-Koyanagi-Harada (VKH) disease.
METHODS
We reviewed the clinical records of two patients who were diagnosed with VKH-like disease during combined interferon-α (IFNα) and ribavirin treatment.
RESULTS
Interruption of IFNα and ribavirin treatment in association with oral corticosteroids resulted in a favorable visual outcome in the case of diffuse retinal detachment (case 1). On the contrary, visual acuity did not improve when late cicatricial stage disease was already present (case 2).
CONCLUSIONS
There is increasing evidence of a link between hepatitis C virus infection treated with pegylated IFNα-2b and the development of VKH-like disease. Knowing the potential side effects of IFNα and ribavirin administration is fundamentally important, as is the need to closely follow up those patients that need to undergo this treatment.
目的
报告两例慢性丙型肝炎感染患者出现类似小柳原田（VKH）病的浆液性视网膜脱离的病例。
方法
我们回顾了两名在联合使用α干扰素（IFNα）和利巴韦林治疗期间被诊断为类VKH病的患者的临床记录。
结果
对于弥漫性视网膜脱离的病例（病例1），中断IFNα和利巴韦林治疗并联合口服皮质类固醇导致了良好的视力结果。相反，当已经出现晚期瘢痕期疾病时（病例2），视力没有改善。
结论
越来越多的证据表明，聚乙二醇化IFNα-2b治疗的丙型肝炎病毒感染与类VKH病的发生之间存在联系。了解IFNα和利巴韦林给药的潜在副作用至关重要，对需要接受这种治疗的患者进行密切随访也很有必要。
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