Kasahara Akinori, Hiraide Atsushi, Tomita Naruya, Iwahashi Hiromi, Imagawa Akihisa, Ohguro Nobuyuki, Yamamoto Shuji, Mita Eiji, Hayashi Norio
Department of General Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-Oka, 565-0871, Suita, Japan.
J Gastroenterol. 2004 Nov;39(11):1106-9. doi: 10.1007/s00535-004-1452-4.
Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C. Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon. Therefore, we conclude that chronic hepatitis C patients, especially people with darkly pigmented skin, need to be closely monitored for ophthalmologic complications, by periodic check-up of the optic fundi, for a prolonged period, during interferon treatment.
视网膜异常，包括视网膜出血和“棉絮斑”，常出现在丙型肝炎慢性患者干扰素治疗过程的前8周内。在此，我们描述1例在α干扰素治疗开始4个月后发生的Vogt-小柳原田病，可能是由干扰素的免疫调节作用诱发的。因此，我们得出结论，丙型肝炎慢性患者，尤其是皮肤色素沉着较深的人，在干扰素治疗期间需要通过定期检查眼底，长期密切监测眼科并发症。
