Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
PLoS One. 2011;6(11):e27664. doi: 10.1371/journal.pone.0027664. Epub 2011 Nov 15.
Human natural killer (NK) cell differentiation, characterized by a loss of NKG2A in parallel with the acquisition of NKG2C, KIRs, and CD57 is stimulated by a number of virus infections, including infection with human cytomegalovirus (CMV), hantavirus, chikungunya virus, and HIV-1. Here, we addressed if HSV-2 infection in a similar way drives NK cell differentiation towards an NKG2A(-)NKG2C(+)KIR(+)CD57(+) phenotype. In contrast to infection with CMV, hantavirus, chikungunya virus, and HIV-1, recurrent HSV-2 infection did not yield an accumulation of highly differentiated NK cells in human peripheral blood. This outcome indicates that human HSV-2 infection has no significant imprinting effect on the human NK cell repertoire.
人类自然杀伤 (NK) 细胞的分化特征是 NKG2A 的丧失与 NKG2C、KIR 和 CD57 的获得平行，这一过程受到多种病毒感染的刺激，包括人类巨细胞病毒 (CMV)、汉坦病毒、基孔肯雅热病毒和 HIV-1 的感染。在这里，我们研究了单纯疱疹病毒 2 型 (HSV-2) 感染是否以类似的方式促使 NK 细胞向 NKG2A(-)NKG2C(+)KIR(+)CD57(+)表型分化。与 CMV、汉坦病毒、基孔肯雅热病毒和 HIV-1 感染不同，复发性单纯疱疹病毒 2 型感染不会导致人类外周血中高度分化的 NK 细胞积累。这一结果表明，人类单纯疱疹病毒 2 型感染对人类 NK 细胞库没有显著的印记效应。
