Kamat Neha P, Katz Joshua S, Hammer Daniel A
Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, Philadelphia PA 19104.
J Phys Chem Lett. 2011 Jul 7;2(13):1612-1623. doi: 10.1021/jz200640x.
The field of biomimicry is embracing the construction of complex assemblies that imitate both biological structure and function. Advancements in the design of these mimetics have generated a growing vision for creating an artificial or proto- cell. Polymersomes are vesicles that can be made from synthetic, biological or hybrid polymers and can be used as a model template to build cell-like structures. In this perspective, we discuss various areas where polymersomes have been used to mimic cell functions as well as areas in which the synthetic flexibility of polymersomes would make them ideal candidates for a biomembrane mimetic. Designing a polymersome that comprehensively displays the behaviors discussed herein has the potential to lead to the development of an autonomous, responsive particle that resembles the intelligence of a biological cell.
仿生学领域正在致力于构建模仿生物结构和功能的复杂组件。这些仿生设计的进展为创造人造细胞或原始细胞带来了越来越清晰的愿景。聚合物囊泡是一种囊泡，可由合成聚合物、生物聚合物或混合聚合物制成，并可用作构建类细胞结构的模型模板。从这个角度出发，我们讨论了聚合物囊泡已被用于模拟细胞功能的各个领域，以及聚合物囊泡的合成灵活性使其成为生物膜模拟理想候选者的领域。设计一种能全面展现本文所讨论行为的聚合物囊泡，有可能促成一种类似生物细胞智能的自主、响应性粒子的开发。
