Jamal S M, Fathil S M, Nidzwani M M, Ismail A K, Yatim F M
Emergency Department, Medical Faculty, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, Cheras, 56000 Kuala Lumpur, Malaysia.
Med J Malaysia. 2011 Aug;66(3):231-3.
The study compared the effectiveness of ketamine and midazolam/fentanyl as procedural sedation and analgesia agents for reduction of fractures and dislocated joints. Forty-one adult patients were enrolled by convenience sampling. They were randomized to receive ketamine or midazolam/fentanyl. Depth of sedation, pain score, procedural outcome and memory of the procedure were documented. The ketamine group had deeper sedation, but there was no statistical difference in other variables between the two groups. Three patients in the midazolam/fentanyl group had oxygen desaturation. More adverse effects were associated with ketamine. Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation.
该研究比较了氯胺酮与咪达唑仑/芬太尼作为用于骨折复位和关节脱位复位的程序性镇静和镇痛药物的有效性。通过方便抽样纳入了41例成年患者。他们被随机分配接受氯胺酮或咪达唑仑/芬太尼。记录了镇静深度、疼痛评分、操作结果和对操作的记忆。氯胺酮组的镇静程度更深，但两组在其他变量上无统计学差异。咪达唑仑/芬太尼组有3例患者出现氧饱和度降低。氯胺酮相关的不良反应更多。静脉注射氯胺酮在程序性镇静方面与咪达唑仑/芬太尼效果相当。
