Hahn K A, Matlock C L
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
J Am Vet Med Assoc. 1990 Aug 15;197(4):491-4.
Diagnosis of nasal adenocarcinoma was made in a 6-year-old 35-kg neutered Golden Retriever and a 6-year-old 8-kg spayed mixed-breed dog with chronic bilateral nasal discharge unresponsive to antibiotics. Treatment for the Golden Retriever consisted of bilateral rhinotomy, curettage, and postoperative fractionated 48-Gy orthovoltage irradiation. The mixed-breed dog was treated with cisplatin. After complete remission of the primary neoplasm, the dogs were reevaluated because of acute lameness. Radiography of the right stifle of the Golden Retriever revealed soft tissue swelling, extensive bony destruction of the distal femoral metaphysis and epiphysis, and pathologic fracture involving the medial condyle. Radiography of the left scapula of the mixed-breed dog revealed lysis of the glenoid cavity and subchondral scapular bone. Diagnosis of metastatic carcinoma was made in both dogs. With treatment improvements and longer survival time of affected dogs, sinonasal neoplasia may be observed to develop in similar life-threatening metastatic sites.
一只6岁、体重35千克已绝育的金毛猎犬和一只6岁、体重8千克已绝育的混血犬，因慢性双侧鼻部分泌物对抗生素治疗无反应，被诊断为鼻腺癌。金毛猎犬的治疗包括双侧鼻切开术、刮除术以及术后48 Gy的分次正交电压照射。混血犬接受了顺铂治疗。原发性肿瘤完全缓解后，两只犬因急性跛行接受了重新评估。金毛猎犬右膝关节的X线检查显示软组织肿胀、股骨远端干骺端和骨骺广泛骨质破坏以及涉及内侧髁的病理性骨折。混血犬左肩胛骨的X线检查显示关节盂腔和肩胛下软骨下骨溶解。两只犬均被诊断为转移性癌。随着治疗方法的改进以及患病犬生存时间的延长，可能会观察到鼻窦肿瘤在类似的危及生命的转移部位发生。
