Madewell B R, Priester W A, Gillette E L, Snyder S P
Am J Vet Res. 1976 Jul;37(7):851-6.
Three hundred cases of primary neoplasms involving the nasal cavity or paranasal sinuses were found among the reports of 12,300 microscopically confirmed neoplasms. The multispecies data were compiled from abstracts of medical records by 13 colleges of veterinary medicine in the United States and Canada from 1964 to 1973. Significant numbers of neoplasms were observed in dogs, horses, and cats. Intranasal neoplasms were more frequent than those of the paranasal sinuses in dogs and cats. Only cats had a sex difference in the occurrence of nasal neoplasms, with a male predilection. The frequency of neoplasms of the nasal cavity and paranasal sinuses increased with age in all species examined. A clear relationship could not be established between nose length and of intranasal neoplasms. Of the tumors, 80% were malignant in dogs, 68% in horses, and 91% in cats. Detailed review of medical records in a subset of 49 dogs with neoplasms of the nasal passage and paranasal sinuses revealed major clinical signs of nasal and ocular discharge, facial deformity, and stertorous breathing. Median duration of signs prior to diagnosis was 3 months and 95% of the dogs had been given treatment prior to definitive diagnosis. All 49 tumors were malignant; 27 were classified histologically as carcinomas and 22 were sarcomas. Nineteen dogs were treated, using surgery alone or in combination with radiation therapy. Median survival duration was 5 months (mean 6.7 mo).
在12300例经显微镜确诊的肿瘤报告中，发现300例原发性肿瘤累及鼻腔或鼻窦。多物种数据汇编自美国和加拿大13所兽医学院1964年至1973年的病历摘要。在犬、马和猫中观察到大量肿瘤。犬和猫的鼻内肿瘤比鼻窦肿瘤更常见。只有猫在鼻腔肿瘤的发生上存在性别差异，雄性更易患病。在所检查的所有物种中，鼻腔和鼻窦肿瘤的发生率均随年龄增长而增加。鼻长与鼻内肿瘤之间无法建立明确的关系。在这些肿瘤中，犬的恶性肿瘤占80%，马的占68%，猫的占91%。对49例患有鼻腔和鼻窦肿瘤的犬的病历进行详细回顾发现，主要临床症状为鼻和眼分泌物增多、面部畸形和呼吸急促。诊断前症状的中位持续时间为3个月，95%的犬在确诊前已接受治疗。所有49个肿瘤均为恶性；27个在组织学上被分类为癌，22个为肉瘤。19只犬接受了单独手术或手术联合放射治疗。中位生存时间为5个月（平均6.7个月）。
